IHC-plus™ C5AR1 / CD88 / C5a Receptor Antibody (clone 10/92) LS-B5229 | LifeSpan Biosciences LS-B5229 product information

product summary

company name :

LifeSpan Biosciences

product type :

antibody

product name :

IHC-plus™ C5AR1 / CD88 / C5a Receptor Antibody (clone 10/92) LS-B5229

catalog :

LS-B5229

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

10/92

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

LifeSpan Biosciences product webpage

citations: 1

Reference
Bisht K, Canesin G, Cheytan T, Li M, Nemeth Z, Csizmadia E, et al. Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway. J Immunol. 2019;202:2982-2990 pubmed publisher

image

image 1 :

Anti-C5AR1 / CD88 antibody IHC of mouse kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

product information

AntibodyID :

139778

AntibodyName :

LS-B5229

TargetSpecies :

Mouse

Host Species :

Rat

Product Name :

IHC-plus™ C5AR1 / CD88 / C5a Receptor Antibody (clone 10/92) LS-B5229

Specificity :

Recognizes murine CD88, a 45kD G-protein coupled cell surface receptor, which is otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, which is a potent proinflammatory molecule and a chemoattractant for neutrophils to sites of infection. In mouse, CD88 is expressed on granulocytes, monocytes and macrophages but not on resting or stimulated lymphocytes. Clone 10/92 does not block the binding of the C5a to murine CD88.

ClonalityDesc :

Monoclonal

CloneName :

10/92

AntibodyModification :

Unconjugated

PresentationDesc :

PBS, 0.09% Sodium Azide

ImmunogenType :

Cells

ImmunogenDesc :

RBL-2H3 transfected cells expressing murine C5aR

PurificationDesc :

Protein G purified

RecommendedStorageDesc :

Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.

IsotypeName :

IgG2a

Gene :

C5AR1 / CD88 / C5a Receptor

StandardGeneSymbol :

C5AR1

gene family :

GPCR

Subfamily :

Anaphylatoxin

Reactivity :

Mouse

Usage :

Flo (1:50 - 1:100), IF, IHC, IHC-Fr, IHC-P (10 µg/ml)

ShortWebDescription :

C5a Receptor antibody LS-B5229 is an unconjugated rat monoclonal antibody to mouse C5a Receptor (C5AR1 / CD88). Validated for Flow, IF and IHC. Cited in 1 publication.

UsageText :

Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul.

Synonyms :

C5AR1, C5A, C5a-R, C5a ligand, C5a receptor, CD88, C5a anaphylatoxin receptor, C5AR, C5R1, CD88 antigen

SalesRegion :

Worldwide

more info or order :

LifeSpan Biosciences product webpage

company information

LifeSpan Biosciences

2401 Fourth Avenue, Suite 900
Seattle, WA 98121

CustomerSupport@lsbio.com

https://www.lsbio.com

1-206-464-1554

headquarters: USA

Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.