product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ IL17 Antibody (clone TC11-18H10) LS-B4912
catalog :
LS-B4912
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
TC11-18H10
reactivity :
mouse
application :
western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Ryu G, Bae J, Kim J, Kim E, Lyu L, Chung Y, et al. Role of IL-17A in Chronic Rhinosinusitis With Nasal Polyp. Allergy Asthma Immunol Res. 2020;12:507-522 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B4912 image 1
Anti-IL-17 antibody IHC of mouse spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
product information
AntibodyID :
126057
AntibodyName :
LS-B4912
TargetSpecies :
Mouse
Host Species :
Rat
Product Name :
IHC-plus™ IL17 Antibody (clone TC11-18H10) LS-B4912
Specificity :
Recognizes mouse Interleukin 17, a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.
ClonalityDesc :
Monoclonal
CloneName :
TC11-18H10
AntibodyModification :
Unconjugated
PresentationDesc :
BBS
ImmunogenDesc :
E. coli-expressed, recombinant mouse IL-17A
PurificationDesc :
Purified from ascites.
RecommendedStorageDesc :
Store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
IsotypeName :
IgG1
Gene :
IL17
StandardGeneSymbol :
IL17
Reactivity :
Mouse
Usage :
ELISA, Flo, IHC, IHC-P (10 µg/ml), WB
ShortWebDescription :
IL17 antibody LS-B4912 is an unconjugated rat monoclonal antibody to mouse IL17. Validated for ELISA, Flow, IHC and WB. Cited in 1 publication.
UsageText :
ELISA: This antibody can be used in a sandwich ELISA with LS-C41752 as a detection antibody.
Synonyms :
, IL17
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.