product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ DNASE1 / DNase I Antibody LS-B4846
catalog :
LS-B4846
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Reference
Pedersen H, Horvei K, Thiyagarajan D, Norby G, Seredkina N, Moroni G, et al. Lupus nephritis: low urinary DNase I levels reflect loss of renal DNase I and may be utilized as a biomarker of disease progression. J Pathol Clin Res. 2018;4:193-203 pubmed publisher
Thiyagarajan D, Pedersen H, Seredkina N, Horvei K, Arranz L, Sonneveld R, et al. IL-1β Promotes a New Function of DNase I as a Transcription Factor for the Fas Receptor Gene. Front Cell Dev Biol. 2018;6:7 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B4846 image 1
Sample (30 ug of whole cell lysate). A: MOLT4. 10% SDS PAGE. DNASE1 antibody diluted at 1:1000
image 2 :
LifeSpan Biosciences LS-B4846 image 2
Anti-DNase I antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
product information
AntibodyID :
124541
AntibodyName :
LS-B4846
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
IHC-plus™ DNASE1 / DNase I Antibody LS-B4846
Specificity :
Human DNase I. Predicted cross-reactivity based on amino acid sequence homology: rabbit (81%), dogs (81%).
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
1X PBS, pH 7, 0.025% ProClin™ 300, 20% Glycerol
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant protein corresponding to human DNase I.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles. Store undiluted.
Gene :
DNASE1 / DNase I
StandardGeneSymbol :
DNASE1
Reactivity :
Human
Usage :
ICC (1:100 - 1:1000), IHC, IHC-P (10 µg/ml), WB (1:500 - 1:3000)
ShortWebDescription :
DNase I antibody LS-B4846 is an unconjugated rabbit polyclonal antibody to human DNase I (DNASE1). Validated for ICC, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
Synonyms :
DNASE1, Deoxyribonuclease I, Deoxyribonuclease i precursor, DNase I, DNL1, DRNI, Deoxyribonuclease-1, DNase I, lysosomal
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.