product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ CASP6 / Caspase 6 Antibody LS-B477
catalog :
LS-B477
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:5000; fig 1d, 1e
  • western blot; human; fig 1c
No xeb l A, Foveau B, LeBlanc A. Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits. Cell Death Dis. 2021;12:227 pubmed publisher
Zhou L, Flores J, Noël A, Beauchet O, Sjöström P, LeBlanc A. Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Acta Neuropathol Commun. 2019;7:210 pubmed publisher
product information
AntibodyID :
31436
AntibodyName :
LS-B477
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
IHC-plus™ CASP6 / Caspase 6 Antibody LS-B477
Specificity :
Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
PresentationDesc :
PBS containing 0.02% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
A 15 AA synthetic peptide near the center of human Caspase-6. The immunogen is located within aa 160-210 of Caspase-6.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Store at 4°C for up 3 months. Store at -20°C for up to 1 year. Avoid freeze/thaw cycles.
IsotypeName :
IgG
Gene :
CASP6 / Caspase 6
BlockingPeptide :
LS-E30124
StandardGeneSymbol :
CASP6
gene family :
Protease
Subfamily :
Cysteine C14
Reactivity :
Human
NonReactiveSpecies :
Mouse, Rat
Usage :
ELISA, ICC, IF, IHC, IHC-P (2.5 µg/ml), WB (1 µg/ml)
ShortWebDescription :
Caspase 6 antibody LS-B477 is an unconjugated rabbit polyclonal antibody to human Caspase 6 (CASP6). Validated for ELISA, ICC, IF, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
UsageText :
Casp-6 antibody can be used for the detection of Caspase-6 by Western blot at 1 and 2 ug/mL. Antibody can also be used for immunocytochemistry starting at 1 ug/mL. For immunofluorescence start at 10 ug/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Western Blot:
Synonyms :
CASP6, Apoptotic protease Mch-2, Caspase 6, CASP-6, Caspase-6, Mch-2, MCH2
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.