product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ CDH11 / Cadherin 11 Antibody (Intracellular) LS-B2308
catalog :
LS-B2308
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 4b
Emori T, Hirose J, Ise K, Yomoda J, Kasahara M, Shinkuma T, et al. Constitutive Activation of Integrin ?9 Augments Self-Directed Hyperplastic and Proinflammatory Properties of Fibroblast-like Synoviocytes of Rheumatoid Arthritis. J Immunol. 2017;199:3427-3436 pubmed publisher
Emori T, Kasahara M, Sugahara S, Hashimoto M, Ito H, Narumiya S, et al. Role of JAK-STAT signaling in the pathogenic behavior of fibroblast-like synoviocytes in rheumatoid arthritis: Effect of the novel JAK inhibitor peficitinib. Eur J Pharmacol. 2020;882:173238 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B2308 image 1
Anti-CDH11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
product information
AntibodyID :
82896
AntibodyName :
LS-B2308
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
IHC-plus™ CDH11 / Cadherin 11 Antibody (Intracellular) LS-B2308
Specificity :
Recognizes human Cadherin 11 at ~110kD. An additional band at ~130kD (presumably the Cadherin 11 precursor) may also be observed. Some crossreactivity with other Cadherins is observed in approximately the following order: Cadherin11>>R-Cadherin>Cadherin 8>>N-Cadherin=P-Cadherin. No crossreactivity with Cadherin 6 or E-Cadherin has been observed.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
Intracellular
PresentationDesc :
PBS, pH 7.4, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant protein derived from the intracellular domain of the human Cadherin 11 protein.
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
CDH11 / Cadherin 11
StandardGeneSymbol :
CDH11
gene family :
Cadherin
Reactivity :
Mouse, Human
Usage :
ELISA (0.1 - 1 µg/ml), IHC, IHC-Fr, IHC-P (5 µg/ml), WB (1 - 2 µg/ml)
ShortWebDescription :
Cadherin 11 antibody LS-B2308 is an unconjugated rabbit polyclonal antibody to Cadherin 11 (CDH11) (Intracellular) from human. It is reactive with human and mouse. Validated for ELISA, IHC and WB. Tested on 20 paraffin-embedded human tissues. Cited in 2 publications.
UsageText :
Immunohistochemistry: LS-B2308 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2308 was determined to be 5 ug/ml. Positive control: MDA. MB231 cells (human) and mouse L fibroblast lysates.
Synonyms :
CDH11, CAD11, Cadherin 11, Cadherin-11, CDHOB, OSF-4, Osteoblast cadherin, OB, OB-cadherin, Ventral neural cadherin, Vnc
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.