product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
PathPlus™ B2M / Beta 2 Microglobulin Antibody (clone 2M2) LS-B2200
catalog :
LS-B2200
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2M2
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 4
Reference
Wise J, Nakken S, Steen C, Vodák D, Trøen G, Johannessen B, et al. Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Adv. 2020;4:1859-1866 pubmed publisher
Meissner T, Liu Y, Lee K, Li A, Biswas A, van Eggermond M, et al. NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression. J Immunol. 2012;188:4951-8 pubmed publisher
Rizvi S, Del Cid N, Lybarger L, Raghavan M. Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules. J Immunol. 2011;186:2309-20 pubmed publisher
Meissner T, Li A, Biswas A, Lee K, Liu Y, Bayir E, et al. NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A. 2010;107:13794-9 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B2200 image 1
Human peripheral blood lymphocytes stained with purified 2M2, followed by anti-mouse FITC.
image 2 :
LifeSpan Biosciences LS-B2200 image 2
Anti-B2M antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
product information
AntibodyID :
62454
AntibodyName :
LS-B2200
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
PathPlus™ B2M / Beta 2 Microglobulin Antibody (clone 2M2) LS-B2200
Specificity :
Purified human beta-2-microglobulin.
ClonalityDesc :
Monoclonal
CloneName :
2M2
AntibodyModification :
Unconjugated
PresentationDesc :
PBS pH 7.2, 0.09% sodium azide.
ImmunogenDesc :
Purified human B2M / Beta-2-Microglobulin.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Store at 2°C to 8°C.
IsotypeName :
IgG1
Gene :
B2M / Beta 2 Microglobulin
StandardGeneSymbol :
B2M
Reactivity :
Human
Usage :
ELISA, Flo, IHC, IHC-P (5 µg/ml), WB
ShortWebDescription :
Beta 2 Microglobulin antibody LS-B2200 is an unconjugated mouse monoclonal antibody to human Beta 2 Microglobulin (B2M). Validated for ELISA, Flow, IHC and WB. Cited in 4 publications.
UsageText :
Immunohistochemistry: LS-B2200 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2200 was determined to be 5 ug/ml.
Synonyms :
B2M, Beta 2 Microglobulin, Beta-2-microglobulin, Beta-2-microglobin
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.