product summary
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company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ HTR3A / 5-HT3A Receptor Antibody (aa21-36) LS-B2042
catalog :
LS-B2042
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 1
Reference
Tone M, Tahara S, Nojima S, Motooka D, Okuzaki D, Morii E. HTR3A is correlated with unfavorable histology and promotes proliferation through ERK phosphorylation in lung adenocarcinoma. Cancer Sci. 2020;111:3953-3961 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-B2042 image 1
Anti-5HT3A receptor antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
product information
AntibodyID :
52992
AntibodyName :
LS-B2042
TargetSpecies :
Rat
Host Species :
Rabbit
Product Name :
IHC-plus™ HTR3A / 5-HT3A Receptor Antibody (aa21-36) LS-B2042
Specificity :
In human brain, a 47-50 kD band is observed.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa21-36
PresentationDesc :
PBS, 0.05% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
This antibody was developed by immunizing rabbits with a mixture of synthetic peptides corresponding to amino acids 21-36 (RATQAHSTTQPALLRL) and 421-436 (LSSIRHSLEKRDEMRE) of rat 5-HT3A receptor, GenBank no AAB02949. Percent identity by BLAST analysis: Rat (100%); Mouse (88%); Hamster (81%).
PurificationDesc :
Protein G purified
RecommendedStorageDesc :
Short term: store at 4°C. Long term: store at -20°C. Avoid freeze-thaw cycles.
IsotypeName :
IgG
Gene :
HTR3A / 5-HT3A Receptor
StandardGeneSymbol :
HTR3A
gene family :
Ion channel
Subfamily :
Serotonin 5-HT3 receptor
Reactivity :
Rat, Human
Usage :
IHC, IHC-P (5 µg/ml), WB (1 µg/ml)
ShortWebDescription :
5-HT3A Receptor antibody LS-B2042 is an unconjugated rabbit polyclonal antibody to 5-HT3A Receptor (HTR3A) (aa21-36) from rat. It is reactive with human and rat. Validated for IHC and WB. Cited in 1 publication.
UsageText :
Immunohistochemistry: LS-B2042 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2042 was determined to be 5 ug/ml.
Synonyms :
HTR3A, 5-HT3-A, 5-HT3R-A, 5-HT3 receptor, 5HT3 serotonin receptor, 5-HT3A, 5-HT3a receptor, 5-hydroxytryptamine receptor 3, 5-HT-3, 5-HT3, 5-HT3R, 5HT3R, HTR3, Serotonin receptor 3A
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.