This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
IHC-plus™ SYK Antibody (aa5-360, clone SYK-01) LS-B11825
catalog :
LS-B11825
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SYK-01

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
product information
AntibodyID :
351287
AntibodyName :
LS-B11825
TargetSpecies :
Human
Host Species :
Mouse
Product Name :
IHC-plus™ SYK Antibody (aa5-360, clone SYK-01) LS-B11825
Specificity :
Recognizes protein tyrosine kinase p72syk (syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in hematopoietic cells, but also expressed by nonhematopoietic cells, including fibroblasts, endothelial cells and hepatocytes. Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase lyn, results in the recruitment of syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathways. Further studies have shown that syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and hematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
ClonalityDesc :
Monoclonal
CloneName :
SYK-01
AntibodyModification :
Unconjugated
AntigenModification :
aa5-360
PresentationDesc :
PBS, 0.09% Sodium Azide
ImmunogenType :
Recombinant protein
ImmunogenDesc :
Recombinant fragment corresponding to aa 5-360 of human Syk.
PurificationDesc :
Protein A purified
RecommendedStorageDesc :
Store at 4°C or at -20°C. Store undiluted. Avoid freeze/thaw cycles.
IsotypeName :
IgG1
Gene :
SYK
StandardGeneSymbol :
SYK
gene family :
Protein Kinase
Subfamily :
Syk/ZAP70
Reactivity :
Human
Usage :
IHC, IHC-P (10 µg/ml), IP, WB
ShortWebDescription :
SYK antibody LS-B11825 is an unconjugated mouse monoclonal antibody to human SYK (aa5-360). Validated for IHC, IP and WB. Tested on 20 paraffin-embedded human tissues.
UsageText :
Western Blot: Detects a band of approximately 72kD in Ramos and RBL cell lysates.
Synonyms :
SYK, p72syk, Spleen tyrosine kinase, Syk protein-tyrosine kinase, Tyrosine-protein kinase SYK, p72-Syk
SalesRegion :
Worldwide
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.