product summary
Loading...
company name :
LifeSpan Biosciences
product type :
antibody
product name :
PathPlus™ HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain) LS-A2685
catalog :
LS-A2685
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
citations: 2
Reference
Le Mestre J, Duparc C, Reznik Y, Bonnet Serrano F, Touraine P, Chabre O, et al. Illicit Upregulation of Serotonin Signaling Pathway in Adrenals of Patients With High Plasma or Intra-Adrenal ACTH Levels. J Clin Endocrinol Metab. 2019;104:4967-4980 pubmed publisher
Louiset E, Duparc C, Lenglet S, Gomez Sanchez C, Lefebvre H. Role of cAMP/PKA pathway and T-type calcium channels in the mechanism of action of serotonin in human adrenocortical cells. Mol Cell Endocrinol. 2017;441:99-107 pubmed publisher
image
image 1 :
LifeSpan Biosciences LS-A2685 image 1
Anti-HTR4 / 5-HT4 Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
image 2 :
LifeSpan Biosciences LS-A2685 image 2
Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
product information
AntibodyID :
1239
AntibodyName :
LS-A2685
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
PathPlus™ HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain) LS-A2685
Specificity :
Human 5HT4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
Cytoplasmic Domain
PresentationDesc :
PBS, 0.1% Sodium Azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic 15 amino acid peptide from 3rd cytoplasmic domain of human 5HT4 Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Panda, Dog, Bat, Bovine, Rabbit, Horse, Pig (100%); Mouse, Rat, Hamster (93%); Guinea pig, Platypus (87%); Lizard (80%).
PurificationDesc :
Immunoaffinity purified
RecommendedStorageDesc :
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Gene :
HTR4 / 5-HT4 Receptor
BlockingPeptide :
LS-E28597
StandardGeneSymbol :
HTR4
gene family :
GPCR
Subfamily :
Serotonin
Reactivity :
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
Usage :
IHC, IHC-P (15 - 20 µg/ml)
ShortWebDescription :
5-HT4 Receptor antibody LS-A2685 is an unconjugated rabbit polyclonal antibody to 5-HT4 Receptor (HTR4) (Cytoplasmic Domain) from human. It is reactive with human, bat, bovine and other species. Validated for IHC. Cited in 2 publications.
Synonyms :
HTR4, 5-HT4, 5-HT4R, 5-HT-4, 5HT4 receptor, 5-HT4 receptor, 5-hydroxytryptamine 4 receptor, 5-hydroxytryptamine receptor 4, Serotonin 5-HT-4a receptor, Serotonin receptor 4, Cardiac 5-HT4 receptor, Serotonin 4 receptor, Serotonin 5-HT-4 receptor
SalesRegion :
Worldwide
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
CustomerSupport@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.