product summary
company name :
Leica Biosystems
other brands :
Novocastra, Surgipath
product type :
antibody
product name :
p53
catalog :
P53-CM5P
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 29
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:250; loading ...; fig 6a
Maurizy C, Abeza C, Lemmers B, Gabola M, Longobardi C, Pinet V, et al. The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium. Nat Commun. 2021;12:4810 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2g
Flowers B, Xu H, Mulligan A, Hanson K, Seoane J, Vogel H, et al. Cell of Origin Influences Pancreatic Cancer Subtype. Cancer Discov. 2021;11:660-677 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 4c
  • immunoprecipitation; human; loading ...; fig 1h
  • western blot; human; loading ...; fig 1h
  • immunoprecipitation; mouse; loading ...; fig 4e
  • western blot; mouse; loading ...; fig 4e
Wang D, Kon N, Lasso G, Jiang L, Leng W, Zhu W, et al. Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode. Nature. 2016;538:118-122 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 2
Guinot A, Oeztuerk Winder F, Ventura J. miR-17-92/p38? Dysregulation Enhances Wnt Signaling and Selects Lgr6+ Cancer Stem-like Cells during Lung Adenocarcinoma Progression. Cancer Res. 2016;76:4012-22 pubmed publisher
Van t Sant L, White J, Hoeijmakers J, Vermeij W, Jaarsma D. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021;9:94 pubmed publisher
Ma S, McGuire M, Mangala L, Lee S, Stur E, Hu W, et al. Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. Cell Rep. 2021;34:108726 pubmed publisher
Peng T, Zhai Y, Atlasi Y, ter Huurne M, Marks H, Stunnenberg H, et al. STARR-seq identifies active, chromatin-masked, and dormant enhancers in pluripotent mouse embryonic stem cells. Genome Biol. 2020;21:243 pubmed publisher
Martire S, Nguyen J, Sundaresan A, Banaszynski L. Differential contribution of p300 and CBP to regulatory element acetylation in mESCs. BMC Mol Cell Biol. 2020;21:55 pubmed publisher
Li Q, Mao F, Zhou B, Huang Y, Zou Z, Dendekker A, et al. p53 Integrates Temporal WDR5 Inputs during Neuroectoderm and Mesoderm Differentiation of Mouse Embryonic Stem Cells. Cell Rep. 2020;30:465-480.e6 pubmed publisher
Chylinski K, Hubmann M, Hanna R, Yanchus C, Michlits G, Uijttewaal E, et al. CRISPR-Switch regulates sgRNA activity by Cre recombination for sequential editing of two loci. Nat Commun. 2019;10:5454 pubmed publisher
Morris J, Yashinskie J, Koche R, Chandwani R, Tian S, Chen C, et al. α-Ketoglutarate links p53 to cell fate during tumour suppression. Nature. 2019;573:595-599 pubmed publisher
Ou H, Kim C, Uszkoreit S, Wickström S, Schumacher B. Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev Cell. 2019;50:167-183.e8 pubmed publisher
Teo Y, Rattanavirotkul N, Olova N, Salzano A, Quintanilla A, Tarrats N, et al. Notch Signaling Mediates Secondary Senescence. Cell Rep. 2019;27:997-1007.e5 pubmed publisher
Santoro A, Vlachou T, Luzi L, Melloni G, Mazzarella L, D Elia E, et al. p53 Loss in Breast Cancer Leads to Myc Activation, Increased Cell Plasticity, and Expression of a Mitotic Signature with Prognostic Value. Cell Rep. 2019;26:624-638.e8 pubmed publisher
Aden K, Bartsch K, Dahl J, Reijns M, Esser D, Sheibani Tezerji R, et al. Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice. Gastroenterology. 2019;156:145-159.e19 pubmed publisher
Furuuchi R, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, et al. Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health. PLoS ONE. 2018;13:e0202051 pubmed publisher
Mahdi A, Huo Y, Tan Y, Simhadri S, Vincelli G, Gao J, et al. Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-?B in Mice with Disengaged BRCA1-PALB2 Interaction. Cancer Res. 2018;78:3969-3981 pubmed publisher
Brandt L, Albers J, Hejhal T, Pfundstein S, Gonçalves A, Catalano A, et al. Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma. Oncotarget. 2018;9:19753-19766 pubmed publisher
Canli O, Nicolas A, Gupta J, Finkelmeier F, Goncharova O, Pesic M, et al. Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis. Cancer Cell. 2017;32:869-883.e5 pubmed publisher
Gonçalves A, Adlesic M, Brandt S, Hejhal T, Harlander S, Sommer L, et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun. 2017;8:1466 pubmed publisher
Mello S, Valente L, Raj N, Seoane J, Flowers B, McClendon J, et al. A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer. Cancer Cell. 2017;32:460-473.e6 pubmed publisher
Van T, Polykratis A, Straub B, Kondylis V, Papadopoulou N, Pasparakis M. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017;127:2662-2677 pubmed publisher
Tonelli C, Morelli M, Sabò A, Verrecchia A, Rotta L, Capra T, et al. Genome-wide analysis of p53-regulated transcription in Myc-driven lymphomas. Oncogene. 2017;36:2921-2929 pubmed publisher
Delbridge A, Pang S, Vandenberg C, Grabow S, Aubrey B, Tai L, et al. RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice. J Exp Med. 2016;213:2039-48 pubmed publisher
Vermeij W, Dollé M, Reiling E, Jaarsma D, Payan Gomez C, Bombardieri C, et al. Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice. Nature. 2016;537:427-431 pubmed publisher
Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed publisher
Page A, Navarro M, Suárez Cabrera C, Alameda J, Casanova M, Paramio J, et al. Protective role of p53 in skin cancer: Carcinogenesis studies in mice lacking epidermal p53. Oncotarget. 2016;7:20902-18 pubmed publisher
Krais A, Speksnijder E, Melis J, Indra R, Moserova M, Godschalk R, et al. The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice. Arch Toxicol. 2016;90:839-51 pubmed publisher
Piazzolla D, Palla A, Pantoja C, Canamero M, de Castro I, Ortega S, et al. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia. Nat Commun. 2014;5:4226 pubmed publisher
company information
Leica Biosystems
hrna@leica-microsystems.com
http://www.leicabiosystems.com