product summary
company name :
Leica Biosystems
other brands :
Novocastra, Surgipath
product type :
antibody
product name :
beta-dystroglycan
catalog :
NCL-b-DG
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
43DAG/8D5
reactivity :
human, mouse, rat, dogs, chicken, rhesus macaque
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; rat; 0.19 ug/ml; loading ...; fig 7
K lm n M, Oszwald E, P csai K. Three-plane description of astroglial populations of OVLT subdivisions in rat: Tanycyte connections to distant parts of third ventricle. J Comp Neurol. 2019;527:2793-2812 pubmed publisher
  • immunohistochemistry; dogs; 1:20; loading ...; fig s15
Amoasii L, Hildyard J, Li H, Sanchez Ortiz E, Mireault A, Caballero D, et al. Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science. 2018;362:86-91 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250-1:500
Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Fukai Y, Ohsawa Y, Ohtsubo H, Nishimatsu S, Hagiwara H, Noda M, et al. Cleavage of ?-dystroglycan occurs in sarcoglycan-deficient skeletal muscle without MMP-2 and MMP-9. Biochem Biophys Res Commun. 2017;492:199-205 pubmed publisher
  • western blot; rat; 1:500; fig 5
Magnowska M, Gorkiewicz T, Suska A, Wawrzyniak M, Rutkowska Wlodarczyk I, Kaczmarek L, et al. Transient ECM protease activity promotes synaptic plasticity. Sci Rep. 2016;6:27757 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:50; fig 4
Janghra N, Morgan J, Sewry C, Wilson F, Davies K, Muntoni F, et al. Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies. PLoS ONE. 2016;11:e0150818 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s7
Tabebordbar M, Zhu K, Cheng J, Chew W, Widrick J, Yan W, et al. In vivo gene editing in dystrophic mouse muscle and muscle stem cells. Science. 2016;351:407-411 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig s8
Nelson C, Hakim C, Ousterout D, Thakore P, Moreb E, Castellanos Rivera R, et al. In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy. Science. 2016;351:403-7 pubmed publisher
  • immunohistochemistry; human; 1:500; loading ...; tbl 1
Shah F, Berggren D, Holmlund T, Levring Jäghagen E, Stål P. Unique expression of cytoskeletal proteins in human soft palate muscles. J Anat. 2016;228:487-94 pubmed publisher
  • western blot; rat; 1:40; fig s2d
Poitelon Y, Bogni S, Matafora V, Della Flora Nunes G, Hurley E, Ghidinelli M, et al. Spatial mapping of juxtacrine axo-glial interactions identifies novel molecules in peripheral myelination. Nat Commun. 2015;6:8303 pubmed publisher
  • western blot; mouse
Sharma P, Basu S, Mitchell R, Stelmack G, Anderson J, Halayko A. Role of dystrophin in airway smooth muscle phenotype, contraction and lung function. PLoS ONE. 2014;9:e102737 pubmed publisher
  • immunohistochemistry - frozen section; rhesus macaque; 1:100
Puthussery T, Gayet Primo J, Taylor W, Haverkamp S. Immunohistochemical identification and synaptic inputs to the diffuse bipolar cell type DB1 in macaque retina. J Comp Neurol. 2011;519:3640-56 pubmed publisher
Sengupta K, Mishra M, Loro E, Spencer M, Pyle A, Khurana T. Genome Editing-Mediated Utrophin Upregulation in Duchenne Muscular Dystrophy Stem Cells. Mol Ther Nucleic Acids. 2020;22:500-509 pubmed publisher
Balci Hayta B, Talim B, Kale G, Dincer P. LARGE expression in different types of muscular dystrophies other than dystroglycanopathy. BMC Neurol. 2018;18:207 pubmed publisher
Patel A, Zhao J, Yue Y, Zhang K, Duan D, Lai Y. Dystrophin R16/17-syntrophin PDZ fusion protein restores sarcolemmal nNOSμ. Skelet Muscle. 2018;8:36 pubmed publisher
Kennedy T, Guiraud S, Edwards B, Squire S, Moir L, Babbs A, et al. Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/mdx Mice. Mol Ther Methods Clin Dev. 2018;11:92-105 pubmed publisher
Yuan J, Ma Y, Huang T, Chen Y, Peng Y, Li B, et al. Genetic Modulation of RNA Splicing with a CRISPR-Guided Cytidine Deaminase. Mol Cell. 2018;72:380-394.e7 pubmed publisher
Poitelon Y, Matafora V, Silvestri N, Zambroni D, McGarry C, Serghany N, et al. A dual role for Integrin α6β4 in modulating hereditary neuropathy with liability to pressure palsies. J Neurochem. 2018;145:245-257 pubmed publisher
Echigoya Y, Nakamura A, Nagata T, Urasawa N, Lim K, Trieu N, et al. Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2017;114:4213-4218 pubmed publisher
Suriyonplengsaeng C, Dejthevaporn C, Khongkhatithum C, Sanpapant S, Tubthong N, Pinpradap K, et al. Immunohistochemistry of sarcolemmal membrane-associated proteins in formalin-fixed and paraffin-embedded skeletal muscle tissue: a promising tool for the diagnostic evaluation of common muscular dystrophies. Diagn Pathol. 2017;12:19 pubmed publisher
Poitelon Y, Lopez Anido C, Catignas K, Berti C, Palmisano M, Williamson C, et al. YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nat Neurosci. 2016;19:879-87 pubmed publisher
Kondratiuk I, Łęski S, Urbańska M, Biecek P, Devijver H, Lechat B, et al. GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology. Mol Neurobiol. 2017;54:200-211 pubmed publisher
Johnson E, Li B, Yoon J, Flanigan K, Martin P, ERVASTI J, et al. Identification of new dystroglycan complexes in skeletal muscle. PLoS ONE. 2013;8:e73224 pubmed publisher
Nakaya Y, Sukowati E, Sheng G. Epiblast integrity requires CLASP and Dystroglycan-mediated microtubule anchoring to the basal cortex. J Cell Biol. 2013;202:637-51 pubmed publisher
Szepesi Z, Bijata M, Ruszczycki B, Kaczmarek L, Wlodarczyk J. Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation. PLoS ONE. 2013;8:e63314 pubmed publisher
Randazzo D, Giacomello E, Lorenzini S, Rossi D, Pierantozzi E, Blaauw B, et al. Obscurin is required for ankyrinB-dependent dystrophin localization and sarcolemma integrity. J Cell Biol. 2013;200:523-36 pubmed publisher
Gupta V, Kawahara G, Myers J, Chen A, Hall T, Manzini M, et al. A splice site mutation in laminin-?2 results in a severe muscular dystrophy and growth abnormalities in zebrafish. PLoS ONE. 2012;7:e43794 pubmed publisher
Smith B, Yue Y, Woods P, Kornegay J, Shin J, Williams R, et al. An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed. Lab Invest. 2011;91:216-31 pubmed publisher
Vogtländer N, Visch H, Bakker M, Berden J, van der Vlag J. Ligation of alpha-dystroglycan on podocytes induces intracellular signaling: a new mechanism for podocyte effacement?. PLoS ONE. 2009;4:e5979 pubmed publisher
Sonnemann K, Heun Johnson H, Turner A, Baltgalvis K, Lowe D, Ervasti J. Functional substitution by TAT-utrophin in dystrophin-deficient mice. PLoS Med. 2009;6:e1000083 pubmed publisher
Bunnell T, Jaeger M, Fitzsimons D, Prins K, Ervasti J. Destabilization of the dystrophin-glycoprotein complex without functional deficits in alpha-dystrobrevin null muscle. PLoS ONE. 2008;3:e2604 pubmed publisher
product information
product code :
NCL-b-DG
product name :
beta-dystroglycan
application :
IHCF
more info or order :
company information
Leica Biosystems
hrna@leica-microsystems.com
http://www.leicabiosystems.com