product summary
company name :
Leica Biosystems
other brands :
Novocastra, Surgipath
product type :
antibody
product name :
Mouse Anti-Human Utrophin Monoclonal Antibody, Unconjugated Conjugated, Clone DRP3/20C5
catalog :
NCL-DRP2
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DRP3/20C5
reactivity :
human, mouse, rhesus macaque
application :
western blot, immunohistochemistry, immunohistochemistry - frozen section
more info or order :
citations: 16
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; fig 1
Janghra N, Morgan J, Sewry C, Wilson F, Davies K, Muntoni F, et al. Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies. PLoS ONE. 2016;11:e0150818 pubmed publisher
  • western blot; mouse; fig 1
Ferry A, Parlakian A, Joanne P, Fraysse B, Mgrditchian T, Roy P, et al. Mechanical Overloading Increases Maximal Force and Reduces Fragility in Hind Limb Skeletal Muscle from Mdx Mouse. Am J Pathol. 2015;185:2012-24 pubmed publisher
  • western blot; mouse
Ljubicic V, Jasmin B. Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle. Muscle Nerve. 2015;52:139-42 pubmed publisher
  • immunohistochemistry; rhesus macaque; loading ...; fig 8c
  • western blot; rhesus macaque; loading ...; fig 8a
Chicoine L, Rodino Klapac L, Shao G, Xu R, Bremer W, Camboni M, et al. Vascular delivery of rAAVrh74.MCK.GALGT2 to the gastrocnemius muscle of the rhesus macaque stimulates the expression of dystrophin and laminin ?2 surrogates. Mol Ther. 2014;22:713-24 pubmed publisher
Mavillard F, Madruga Garrido M, Rivas E, Servián Morilla E, Ávila Polo R, Marcos I, et al. NOVEL intronic CAPN3 Roma mutation alters splicing causing RNA mediated decay. Ann Clin Transl Neurol. 2019;6:2328-2333 pubmed publisher
Sánchez L, Beltran E, De Stefani A, Guo L, Shea A, Shelton G, et al. Clinical and genetic characterisation of dystrophin-deficient muscular dystrophy in a family of Miniature Poodle dogs. PLoS ONE. 2018;13:e0193372 pubmed publisher
Carlson C, Moore S, Mathews K. Dystrophinopathy muscle biopsies in the genetic testing ERA: One center's data. Muscle Nerve. 2018;: pubmed publisher
Packer R, Logan M, Guo L, Apte S, Bader H, O Brien D, et al. Clinical Phenotype of Musladin-Lueke Syndrome in 2 Beagles. J Vet Intern Med. 2017;31:532-538 pubmed publisher
Al Sarraj S, King A, Cleveland M, Pradat P, Corse A, Rothstein J, et al. Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study. Acta Neuropathol Commun. 2014;2:165 pubmed publisher
Larcher T, Lafoux A, Tesson L, Remy S, Thepenier V, François V, et al. Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy. PLoS ONE. 2014;9:e110371 pubmed publisher
Amirouche A, Tadesse H, Miura P, Belanger G, Lunde J, Cote J, et al. Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle. Nucleic Acids Res. 2014;42:3982-97 pubmed publisher
Chandrasekharan K, Yoon J, Xu Y, DeVries S, Camboni M, Janssen P, et al. A human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophy. Sci Transl Med. 2010;2:42ra54 pubmed publisher
Guerron A, Rawat R, Sali A, Spurney C, Pistilli E, Cha H, et al. Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy. PLoS ONE. 2010;5:e11220 pubmed publisher
Gambardella S, Rinaldi F, Lepore S, Viola A, Loro E, Angelini C, et al. Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. J Transl Med. 2010;8:48 pubmed publisher
Mattei E, Corbi N, Di Certo M, Strimpakos G, Severini C, Onori A, et al. Utrophin up-regulation by an artificial transcription factor in transgenic mice. PLoS ONE. 2007;2:e774 pubmed
Burkin D, Wallace G, Nicol K, Kaufman D, Kaufman S. Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice. J Cell Biol. 2001;152:1207-18 pubmed
company information
Leica Biosystems
hrna@leica-microsystems.com
http://www.leicabiosystems.com