ELISA/assay

KRIBIOLISA™ Teclistamab ELISA

KBI1667

1 x 96 wells

1050 USD

KRIBIOLISA™ Teclistamab ELISA

ELISA

1 x 96 wells

1050 USD

Teclistamab ELISA for quantitative determination of Teclistamab in human serum, plasma Krishgen PK kits, developed using the innovator drug as calibrator, are used for the quantitation of serum protein drug levels, and can be used for biosimilar and generics research as well. About the kit: - Uses anti-idiotypic antibodies sourced from our vendor partner in the US, which ensures higher specificity, and low cross reactivity. - Recovery rates are between 85 - 115% - Ready to use with a standard protocol with break-apart pre-coated wells - Validated as per US FDA guidelines for Bioassays - Optimized for matrix effects to ensure higher sensitivity. - Shelf life: 1 year

Human

Teclistamab is a bispecific T-cell engager antibody that targets both B-cell maturation antigen (BCMA) expressed on the surface of myeloma cells and the CD3 receptor expressed on the surface of T cells. The FDA in Oct 2022 granted approval to Janssen Biotech’s Teclistamab (TECVAYLI) for treatment of relapsed or refractory multiple myeloma, marking a new class of therapy now available for patients whose disease had progressed on other types of therapy.

This ELISA kit comes with a pre-coated plate, concentrated or lyophilized standards, wash solution, subtrate, stop solution and all the required diluents. For the exact contents of the kit, please refer to the datasheet / IFU.

2-8 Deg C

0 ng/ml - 1000 ng/ml

15.6 ng/ml

The method employs indirect sandwich ELISA technique. Recombinant BCMA protein is pre-coated onto microwells. Samples and Teclistamab standards are pipetted into microwells and bound by the capture protein. After incubation the wells are washed and followed by addition of HRP-conjugated CD3 protein into each well and incubated to form a complex. After washing microwells in order to remove any non-specific binding, the substrate solution (TMB) is added to microwells and color develops proportionally to the amount of Teclistamab in the sample. Color development is then stopped by addition of stop solution. Absorbance is measured at 450 nm.

Teclistamab

RUO

2-8 degrees C