ELISA/assay

KRIBIOLISA™ Risankizumab (SKYRIZI) ELISA

KBI1593

1 x 96 wells

1050 USD

KRIBIOLISA™ Risankizumab (SKYRIZI) ELISA

ELISA

1 x 96 wells

1050 USD

Risankizumab (SKYRIZI) ELISA for quantitative determination of Risankizumab (SKYRIZI) in human serum, plasma Krishgen PK kits, developed using the innovator drug as calibrator, are used for the quantitation of serum protein drug levels, and can be used for biosimilar and generics research as well. About the kit: - Uses anti-idiotypic antibodies sourced from our vendor partner in the US, which ensures higher specificity, and low cross reactivity. - Recovery rates are between 85 - 115% - Ready to use with a standard protocol with break-apart pre-coated wells - Validated as per US FDA guidelines for Bioassays - Optimized for matrix effects to ensure higher sensitivity. - Shelf life: 1 year

Human

Risankizumab is a humanized immunoglobulin (Ig) G1 monoclonal antibody that specifically targets the p19 subunit of interleukin (IL)-23, thereby inhibiting IL-23-dependent cell signaling. Risankizumab was approved by the U.S. FDA for treatment of moderate-to-severe plaque psoriasis in April 2019, and in vitro, has been more potent in inhibiting IL-23 signalling than other drugs performing in the same IL-23 complex.

This ELISA kit comes with a pre-coated plate, concentrated or lyophilized standards, wash solution, subtrate, stop solution and all the required diluents. For the exact contents of the kit, please refer to the datasheet / IFU.

2-8 Deg C

0 ng/ml - 640 ng/ml

7.5 ng/ml

IL-23A Protein is pre-coated onto microwells. Samples and standards are pipetted into microwells. Risankizumab present in the sample is bound by the protein. Then, an Anti-Human IgG conjugated to HRP is pipetted and incubated. After washing microwells, in order to remove any non-specific binding, the ready to use substrate solution (TMB) is added to microwells and color develops proportionally to the amount of Risankizumab in the sample. Color development is then stopped by addition of stop solution. Absorbance is measured at 450 nm.

Risankizumab

RUO

2-8 degrees C