Biotin-SP (long spacer) AffiniPure™ F(ab')2 fragment Goat Anti-Human IgG, Fcγ fragment specific (min X Bov, Hrs, Ms Sr Prot) | Jackson ImmunoResearch Laboratories 109-066-098 product information

product summary

company name :

Jackson ImmunoResearch Laboratories

product type :

secondary antibody

product name :

Biotin-SP (long spacer) AffiniPure™ F(ab')2 fragment Goat Anti-Human IgG, Fcγ fragment specific (min X Bov, Hrs, Ms Sr Prot)

catalog :

109-066-098

quantity :

0.5 ml

price :

158 USD

more info or order :

Jackson ImmunoResearch Laboratories product webpage

citations: 7

Reference
Järnum S, Runström A, Bockermann R, Winstedt L, Crispin M, Kjellman C. Enzymatic Inactivation of Endogenous IgG by IdeS Enhances Therapeutic Antibody Efficacy. Mol Cancer Ther. 2017;16:1887-1897 pubmed publisher
Moritz B, Woltering L, Becker P, Göpfert U. High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells. Biotechnol Prog. 2016;32:776-86 pubmed publisher
JÃ¤rnum S, Bockermann R, RunstrÃ¶m A, Winstedt L, Kjellman C. The Bacterial Enzyme IdeS Cleaves the IgG-Type of B Cell Receptor (BCR), Abolishes BCR-Mediated Cell Signaling, and Inhibits Memory B Cell Activation. J Immunol. 2015;195:5592-601 pubmed publisher
Winstedt L, Järnum S, Nordahl E, Olsson A, Runström A, Bockermann R, et al. Complete Removal of Extracellular IgG Antibodies in a Randomized Dose-Escalation Phase I Study with the Bacterial Enzyme IdeS--A Novel Therapeutic Opportunity. PLoS ONE. 2015;10:e0132011 pubmed publisher
Lyon R, Bovee T, Doronina S, Burke P, Hunter J, Neff LaFord H, et al. Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index. Nat Biotechnol. 2015;33:733-5 pubmed publisher
Link A, Hardie D, Favre S, Britschgi M, Adams D, Sixt M, et al. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. Am J Pathol. 2011;178:1662-75 pubmed publisher
Frasca D, Diaz A, Romero M, Landin A, Phillips M, Lechner S, et al. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine. 2010;28:8077-84 pubmed publisher

product information

Catalog Number :

109-066-098

Product Name :

Biotin-SP (long spacer) AffiniPure™ F(ab')2 fragment Goat Anti-Human IgG, Fcγ fragment specific (min X Bov, Hrs, Ms Sr Prot)

Product Type :

Secondary Antibody

Host Species :

Goat

Clonality :

Polyclonal

Conjugation :

Biotin-SP (long spacer)

Size :

0.5 ml

USD List Price :

158 USD

Euro List Price :

209

Product Description :

Based on immunoelectrophoresis and/or ELISA, the antibody reacts with the Fc portion of human IgG heavy chain but not with the Fab portion of human IgG. No antibody was detected against human IgM or IgA, or against non-immunoglobulin serum proteins. The antibody has been tested by ELISA and/or solid-phase adsorbed to ensure minimal cross-reaction with bovine, horse and mouse serum proteins, but it may cross-react with immunoglobulins from other species.

CrossReactivity :

Human

Specificity :

IgG, Fcγ fragment

more info or order :

Jackson ImmunoResearch Laboratories product webpage