TCR V alpha 12.1 Monoclonal Antibody (6D6.6), FITC | Invitrogen TCR2764 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 12.1 Monoclonal Antibody (6D6.6), FITC

catalog :

TCR2764

quantity :

200 Tests

price :

US 440.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

6D6.6

reactivity :

human

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Fazilleau N, Bachelez H, Gougeon M, Viguier M. Cutting edge: size and diversity of CD4+CD25high Foxp3+ regulatory T cell repertoire in humans: evidence for similarities and partial overlapping with CD4+CD25- T cells. J Immunol. 2007;179:3412-6 pubmed
	Carter J, Preall J, Atwal G. Bayesian Inference of Allelic Inclusion Rates in the Human T Cell Receptor Repertoire. Cell Syst. 2019;9:475-482.e4 pubmed publisher
	Tao C, Shao H, Zhang W, Bo H, Wu F, Shen H, et al. ??TCR immunoglobulin constant region domain exchange in human ??TCRs improves TCR pairing without altering TCR gene-modified T cell function. Mol Med Rep. 2017;15:1555-1564 pubmed publisher
	Govers C, SebestyÃ©n Z, Roszik J, van Brakel M, Berrevoets C, SzÃ¶Å‘r Ã, et al. TCRs genetically linked to CD28 and CD3Îµ do not mispair with endogenous TCR chains and mediate enhanced T cell persistence and anti-melanoma activity. J Immunol. 2014;193:5315-26 pubmed publisher
	DerSimonian H, Sugita M, Glass D, Maier A, Weinblatt M, Reme T, et al. Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med. 1993;177:1623-31 pubmed
	Janson C, Grunewald J, Osterborg A, DerSimonian H, Brenner M, Mellstedt H, et al. Predominant T cell receptor V gene usage in patients with abnormal clones of B cells. Blood. 1991;77:1776-80 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 12.1 Monoclonal Antibody (6D6.6), FITC

Catalog # :

TCR2764

Quantity :

200 Tests

Price :

US 440.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1:20, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Species :

Human

Clone :

6D6.6

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V alpha 12.1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:20, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Aliases :

TCRVA; TCRVA 12.1; V alpha 12.1; V alpha-12.1 TCR

more info or order :

Invitrogen product webpage