TCR V beta 3.1 Monoclonal Antibody (8F10), FITC | Invitrogen TCR2740 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 3.1 Monoclonal Antibody (8F10), FITC

catalog :

TCR2740

quantity :

200 Tests

price :

US 449.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

8F10

reactivity :

African green monkey, human

application :

immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 5a	Moura J, Rodrigues J, Goncalves M, Amaral C, Lima M, Carvalho E. Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol. 2017;14:758-769 pubmed publisher
flow cytometry; African green monkey	Gong G, Shao L, Wang Y, Chen C, Huang D, Yao S, et al. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood. 2009;113:837-45 pubmed publisher
immunocytochemistry; human	Mack C, Falta M, Sullivan A, Karrer F, Sokol R, Freed B, et al. Oligoclonal expansions of CD4+ and CD8+ T-cells in the target organ of patients with biliary atresia. Gastroenterology. 2007;133:278-87 pubmed
immunohistochemistry; human	Englund P, Wahlstrom J, Fathi M, Rasmussen E, Grunewald J, Tornling G, et al. Restricted T cell receptor BV gene usage in the lungs and muscles of patients with idiopathic inflammatory myopathies. Arthritis Rheum. 2007;56:372-83 pubmed
	Veatch J, Lee S, Shasha C, Singhi N, Szeto J, Moshiri A, et al. Neoantigen-specific CD4+ T cells in human melanoma have diverse differentiation states and correlate with CD8+ T cell, macrophage, and B cell function. Cancer Cell. 2022;40:393-409.e9 pubmed publisher
	Olsson T, Edenius C, Ferm M, Samuelson P, Torrång A, Wallstrom E, et al. Depletion of Vbeta5.2/5.3 T cells with a humanized antibody in patients with multiple sclerosis. Eur J Neurol. 2002;9:153-64 pubmed
	Charini W, Kuroda M, Schmitz J, Beaudry K, Lin W, Lifton M, et al. Clonally diverse CTL response to a dominant viral epitope recognizes potential epitope variants. J Immunol. 2001;167:4996-5003 pubmed
	Eick A, Larned J, Jason J. Effects of HIV-1 peptides on T-cell receptor variable beta chain families. Hum Immunol. 2000;61:993-1000 pubmed
	Striebich C, Falta M, Wang Y, Bill J, Kotzin B. Selective accumulation of related CD4+ T cell clones in the synovial fluid of patients with rheumatoid arthritis. J Immunol. 1998;161:4428-36 pubmed
	Subauste C, Fuh F, de Waal Malefyt R, Remington J. Alpha beta T cell response to Toxoplasma gondii in previously unexposed individuals. J Immunol. 1998;160:3403-11 pubmed
	Lamphear J, Bohach G, Rich R. Structural dichotomy of staphylococcal enterotoxin C superantigens leading to MHC class II-independent activation of T lymphocytes. J Immunol. 1998;160:2107-14 pubmed
	Zaremba S, Barzaga E, Zhu M, Soares N, Tsang K, Schlom J. Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997;57:4570-7 pubmed
	Calaman S, Carson G, Henry L, Kubinec J, Kuestner R, Ahmed A, et al. Characterization of monoclonal antibodies specific for the V beta 3 family of the human T cell receptor generated using soluble TCR beta-chain. J Immunol Methods. 1993;164:233-44 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 3.1 Monoclonal Antibody (8F10), FITC

Catalog # :

TCR2740

Quantity :

200 Tests

Price :

US 449.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent

Species :

Human

Clone :

8F10

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V beta 3.1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

T cell receptor beta locus; TCRB; TRB; TRB@

more info or order :

Invitrogen product webpage