TCR V alpha 2 Monoclonal Antibody (F1), FITC | Invitrogen TCR2663 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 2 Monoclonal Antibody (F1), FITC

catalog :

TCR2663

quantity :

200 Tests

price :

US 427.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

reactivity :

human

application :

western blot, flow cytometry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human	Thomas S, Xue S, Cesco Gaspere M, San José E, Hart D, Wong V, et al. Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells. J Immunol. 2007;179:5803-10 pubmed
	El Shabrawi Caelen L, Cerroni L, Medeiros L, McCalmont T. Hypopigmented mycosis fungoides: frequent expression of a CD8+ T-cell phenotype. Am J Surg Pathol. 2002;26:450-7 pubmed
	Korhonen M, Ormio M, Burgeson R, Virtanen I, Savilahti E. Unaltered distribution of laminins, fibronectin, and tenascin in celiac intestinal mucosa. J Histochem Cytochem. 2000;48:1011-20 pubmed
	Rantala I, Collin P, Holm K, Kainulainen H, Mustonen J, Maki M. Small bowel T cells, HLA class II antigen DR, and GroEL stress protein in IgA nephropathy. Kidney Int. 1999;55:2274-80 pubmed
	Sano S, Matsui Y, Itami S, Yoshikawa K. Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome. Clin Exp Immunol. 1998;113:190-7 pubmed
	Boylston A, Borst J, Yssel H, Blanchard D, Spits H, de Vries J. Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes. J Immunol. 1986;137:741-4 pubmed
	Axberg I, Gale M, Afar B, Clark E. Characterization of T-cell subsets and T-cell receptor subgroups in pigtailed macaques using two- and three-color flow cytometry. J Clin Immunol. 1991;11:193-204 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 2 Monoclonal Antibody (F1), FITC

Catalog # :

TCR2663

Quantity :

200 Tests

Price :

US 427.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: 1-2 ug/test

Species :

Human, Non-human primate

Clone :

Isotype :

IgG2a

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V alpha-2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test

Aliases :

TCRVA; TCRVA2; V alpha 2; V alpha-2 TCR; Va 2; Va2; Valpha 2; Valpha2

more info or order :

Invitrogen product webpage