TCR V beta 12 Monoclonal Antibody (S511), FITC | Invitrogen TCR2654 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 12 Monoclonal Antibody (S511), FITC

catalog :

TCR2654

quantity :

200 Tests

price :

US 488.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

S511

reactivity :

human, mouse

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse	Mehrotra S, Al Khami A, Klarquist J, Husain S, Naga O, Eby J, et al. A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice. J Immunol. 2012;189:1627-38 pubmed publisher
	Wang J, Urbanska K, Sharma P, Nejati R, Shaw L, Lim M, et al. A Novel Approach for the Treatment of T Cell Malignancies: Targeting T Cell Receptor Vβ Families. Vaccines (Basel). 2020;8: pubmed publisher
	Chatterjee S, Daenthanasanmak A, Chakraborty P, Wyatt M, Dhar P, Selvam S, et al. CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response. Cell Metab. 2018;27:85-100.e8 pubmed publisher
	Olsson T, Edenius C, Ferm M, Samuelson P, Torrång A, Wallstrom E, et al. Depletion of Vbeta5.2/5.3 T cells with a humanized antibody in patients with multiple sclerosis. Eur J Neurol. 2002;9:153-64 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 12 Monoclonal Antibody (S511), FITC

Catalog # :

TCR2654

Quantity :

200 Tests

Price :

US 488.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 10 uL/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Species :

Human

Clone :

S511

Isotype :

IgG2b

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V beta 12

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 10 uL/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Aliases :

T cell receptor beta chain; T cell receptor beta locus; TCRB; TCRbeta; Tib; TRB; TRB@

more info or order :

Invitrogen product webpage