TCR V beta 5b Monoclonal Antibody (W112), FITC | Invitrogen TCR2645 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 5b Monoclonal Antibody (W112), FITC

catalog :

TCR2645

quantity :

150 Tests

price :

US 384.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

W112

The same clone is also sold as:

Novus Biologicals: NBP2-22500
Abcam: ab171099

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

citations: 2

Reference
Raulf Heimsoth M, Merget R, Rihs H, Föhring M, Liebers V, Gellert B, et al. T-cell receptor repertoire expression in workers with occupational asthma due to platinum salt. Eur Respir J. 2000;16:871-8 pubmed
Poppema S, Hepperle B. Restricted V gene usage in T-cell lymphomas as detected by anti-T-cell receptor variable region reagents. Am J Pathol. 1991;138:1479-84 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 5b Monoclonal Antibody (W112), FITC

Catalog # :

TCR2645

Quantity :

150 Tests

Price :

US 384.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

W112

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR Vb5.3

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

T cell receptor beta locus; TCRB; TRB; TRB@