TCR V beta 5a Monoclonal Antibody (1C1), FITC | Invitrogen TCR2642 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 5a Monoclonal Antibody (1C1), FITC

catalog :

TCR2642

quantity :

200 Tests

price :

US 488.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

1C1

reactivity :

African green monkey, human, mouse

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Aggen D, Chervin A, Schmitt T, Engels B, Stone J, Richman S, et al. Single-chain V?V? T-cell receptors function without mispairing with endogenous TCR chains. Gene Ther. 2012;19:365-74 pubmed publisher
flow cytometry; African green monkey	Gong G, Shao L, Wang Y, Chen C, Huang D, Yao S, et al. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood. 2009;113:837-45 pubmed publisher
	Eick A, Larned J, Jason J. Effects of HIV-1 peptides on T-cell receptor variable beta chain families. Hum Immunol. 2000;61:993-1000 pubmed
	Mugnaini E, Egeland T, Spurkland A, Brinchmann J. The T cell receptor repertoire of CD8+CD28- T lymphocytes is dominated by expanded clones that persist over time. Clin Exp Immunol. 1999;117:298-303 pubmed
	Akatsuka Y, Martin E, Madonik A, Barsoukov A, Hansen J. Rapid screening of T-cell receptor (TCR) variable gene usage by multiplex PCR: application for assessment of clonal composition. Tissue Antigens. 1999;53:122-34 pubmed
	Baca Estrada M, Wong D, Croitoru K. Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol. 1995;99:398-403 pubmed
	Boylston A, Borst J, Yssel H, Blanchard D, Spits H, de Vries J. Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes. J Immunol. 1986;137:741-4 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 5a Monoclonal Antibody (1C1), FITC

Catalog # :

TCR2642

Quantity :

200 Tests

Price :

US 488.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Non-human primate

Applications :

Flow Cytometry: 2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, T-Cell Activation: Assay-dependent

Species :

Human, Mouse, Non-human primate

Clone :

1C1

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V beta 5(a)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, T-Cell Activation: Assay-dependent

Aliases :

T cell receptor beta chain; T cell receptor beta locus; TCRB; TCRbeta; Tib; TRB; TRB@

more info or order :

Invitrogen product webpage