TCR gamma/delta Monoclonal Antibody (5A6.E9), FITC | Invitrogen TCR2061 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR gamma/delta Monoclonal Antibody (5A6.E9), FITC

catalog :

TCR2061

quantity :

200 Tests

price :

US 488.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

5A6.E9

reactivity :

human

application :

immunohistochemistry, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Garcia Herrera A, Song J, Chuang S, Villamor N, Colomo L, Pittaluga S, et al. Nonhepatosplenic Î³Î´ T-cell lymphomas represent a spectrum of aggressive cytotoxic T-cell lymphomas with a mainly extranodal presentation. Am J Surg Pathol. 2011;35:1214-25 pubmed publisher
blocking or activating experiments; human	Gold M, Cerri S, Smyk Pearson S, Cansler M, Vogt T, Delepine J, et al. Human mucosal associated invariant T cells detect bacterially infected cells. PLoS Biol. 2010;8:e1000407 pubmed publisher
flow cytometry; human	Hedlund M, Stenqvist A, Nagaeva O, Kjellberg L, Wulff M, Baranov V, et al. Human placenta expresses and secretes NKG2D ligands via exosomes that down-modulate the cognate receptor expression: evidence for immunosuppressive function. J Immunol. 2009;183:340-51 pubmed publisher
immunohistochemistry; human; 1:50	Hölttä V, Klemetti P, Sipponen T, Westerholm Ormio M, Kociubinski G, Salo H, et al. IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm Bowel Dis. 2008;14:1175-84 pubmed publisher
flow cytometry; human	Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
	Cansler M, Null M, Meermeier E, Swarbrick G, LEWINSOHN D, Harriff M. Generation of MR1-Restricted T Cell Clones by Limiting Dilution Cloning of MR1 Tetramer+ Cells. Methods Mol Biol. 2020;2098:219-235 pubmed publisher
	Takeshita M, Imayama S, Oshiro Y, Kurihara K, Okamoto S, Matsuki Y, et al. Clinicopathologic analysis of 22 cases of subcutaneous panniculitis-like CD56- or CD56+ lymphoma and review of 44 other reported cases. Am J Clin Pathol. 2004;121:408-16 pubmed
	Brandes M, Willimann K, Lang A, Nam K, Jin C, Brenner M, et al. Flexible migration program regulates gamma delta T-cell involvement in humoral immunity. Blood. 2003;102:3693-701 pubmed
	DeSantis S, Pau C, Archibald L, Nwanyanwu O, Kazembe P, Dobbie H, et al. Demographic and immune correlates of human herpesvirus 8 seropositivity in Malawi, Africa. Int J Infect Dis. 2002;6:266-71 pubmed
	Korhonen M, Ormio M, Burgeson R, Virtanen I, Savilahti E. Unaltered distribution of laminins, fibronectin, and tenascin in celiac intestinal mucosa. J Histochem Cytochem. 2000;48:1011-20 pubmed
	Rantala I, Collin P, Holm K, Kainulainen H, Mustonen J, Maki M. Small bowel T cells, HLA class II antigen DR, and GroEL stress protein in IgA nephropathy. Kidney Int. 1999;55:2274-80 pubmed
	Seko Y, Ishiyama S, Nishikawa T, Kasajima T, Hiroe M, Kagawa N, et al. Restricted usage of T cell receptor V alpha-V beta genes in infiltrating cells in the hearts of patients with acute myocarditis and dilated cardiomyopathy. J Clin Invest. 1995;96:1035-41 pubmed
	Halstensen T, Scott H, Brandtzaeg P. Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease. Scand J Immunol. 1989;30:665-72 pubmed
	Falini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli M, et al. Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J Immunol. 1989;143:2480-8 pubmed
	Malkovsky M, Bartz S, Mackenzie D, Radtke B, Wallace M, Manning J, et al. Are gamma delta T cells important for the elimination of virus-infected cells?. J Med Primatol. 1992;21:113-8 pubmed

product information

Product Type :

Antibody

Product Name :

TCR gamma/delta Monoclonal Antibody (5A6.E9), FITC

Catalog # :

TCR2061

Quantity :

200 Tests

Price :

US 488.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test

Species :

Human

Clone :

5A6.E9

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Pan TCR gamma delta

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test

Aliases :

RGD1311300; similar to T cell receptor V delta 6; T cell receptor gamma locus; T3/TCR complex; TCR delta gamma; TCR gamma/delta; TCR-CD3 complex; Tcrg; Trg; Trg@

more info or order :

Invitrogen product webpage