TCR delta Monoclonal Antibody (TS-1), FITC | Invitrogen TCR2055 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR delta Monoclonal Antibody (TS-1), FITC

catalog :

TCR2055

quantity :

200 Tests

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

TS-1

reactivity :

human

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 2a	Tham M, SchlÃ¶r G, Yerly D, Mueller C, Surbek D, Villiger P, et al. Reduced pro-inflammatory profile of Î³Î´T cells in pregnant patients with rheumatoid arthritis. Arthritis Res Ther. 2016;18:26 pubmed publisher
flow cytometry; human; fig s1	Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, et al. Effector VÎ³9VÎ´2 T cells dominate the human fetal Î³Î´ T-cell repertoire. Proc Natl Acad Sci U S A. 2015;112:E556-65 pubmed publisher
flow cytometry; human	Vermijlen D, Brouwer M, Donner C, Liesnard C, Tackoen M, Van Rysselberge M, et al. Human cytomegalovirus elicits fetal gammadelta T cell responses in utero. J Exp Med. 2010;207:807-21 pubmed publisher
flow cytometry; human	Barcy S, De Rosa S, Vieira J, Diem K, Ikoma M, Casper C, et al. Gamma delta+ T cells involvement in viral immune control of chronic human herpesvirus 8 infection. J Immunol. 2008;180:3417-25 pubmed
flow cytometry; human	Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
	Lee M, Lee E, Han S, Choi Y, Kwon D, Choi H, et al. Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells. Nat Commun. 2020;11:4367 pubmed publisher
	Cimini E, Castilletti C, Sacchi A, Casetti R, Bordoni V, Romanelli A, et al. Human Zika infection induces a reduction of IFN-γ producing CD4 T-cells and a parallel expansion of effector Vδ2 T-cells. Sci Rep. 2017;7:6313 pubmed publisher
	Poccia F, Boullier S, Lecoeur H, Cochet M, Poquet Y, Colizzi V, et al. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol. 1996;157:449-61 pubmed
	Bottino C, Tambussi G, Ferrini S, Ciccone E, Varese P, Mingari M, et al. Two subsets of human T lymphocytes expressing gamma/delta antigen receptor are identifiable by monoclonal antibodies directed to two distinct molecular forms of the receptor. J Exp Med. 1988;168:491-505 pubmed
	Halstensen T, Scott H, Brandtzaeg P. Intraepithelial T cells of the TcR gamma/delta+ CD8- and V delta 1/J delta 1+ phenotypes are increased in coeliac disease. Scand J Immunol. 1989;30:665-72 pubmed
	Falini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli M, et al. Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J Immunol. 1989;143:2480-8 pubmed
	Miossec C, Faure F, Ferradini L, Roman Roman S, Jitsukawa S, Ferrini S, et al. Further analysis of the T cell receptor gamma/delta+ peripheral lymphocyte subset. The V delta 1 gene segment is expressed with either C alpha or C delta. J Exp Med. 1990;171:1171-88 pubmed
	Carding S, McNamara J, Pan M, Bottomly K. Characterization of gamma/delta T cell clones isolated from human fetal liver and thymus. Eur J Immunol. 1990;20:1327-35 pubmed
	Janssen O, Wesselborg S, Heckl Ostreicher B, Pechhold K, Bender A, Schondelmaier S, et al. T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells. J Immunol. 1991;146:35-9 pubmed

product information

Product Type :

Antibody

Product Name :

TCR delta Monoclonal Antibody (TS-1), FITC

Catalog # :

TCR2055

Quantity :

200 Tests

Price :

US 491.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test

Species :

Human

Clone :

TS-1

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR Vdelta1-Jdelta2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test

Aliases :

CD3 antigen; CD3d antigen; OKT3

more info or order :

Invitrogen product webpage