TCR V alpha 12.1 Monoclonal Antibody (6D6.6) | Invitrogen TCR1764 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 12.1 Monoclonal Antibody (6D6.6)

catalog :

TCR1764

quantity :

200 ug

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6D6.6

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Gebe J, Yue B, Unrath K, Falk B, Nepom G. Restricted autoantigen recognition associated with deletional and adaptive regulatory mechanisms. J Immunol. 2009;183:59-65 pubmed publisher
flow cytometry; mouse	Gebe J, Unrath K, Yue B, Miyake T, Falk B, Nepom G. Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice. J Autoimmun. 2008;30:197-206 pubmed
flow cytometry; human	Fazilleau N, Bachelez H, Gougeon M, Viguier M. Cutting edge: size and diversity of CD4+CD25high Foxp3+ regulatory T cell repertoire in humans: evidence for similarities and partial overlapping with CD4+CD25- T cells. J Immunol. 2007;179:3412-6 pubmed
	Ali R, Babad J, Follenzi A, Gebe J, Brehm M, Nepom G, et al. Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease. Immunology. 2016;148:339-51 pubmed publisher
	Zaremba S, Barzaga E, Zhu M, Soares N, Tsang K, Schlom J. Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997;57:4570-7 pubmed
	DerSimonian H, Sugita M, Glass D, Maier A, Weinblatt M, Reme T, et al. Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients. J Exp Med. 1993;177:1623-31 pubmed
	DerSimonian H, Band H, Brenner M. Increased frequency of T cell receptor V alpha 12.1 expression on CD8+ T cells: evidence that V alpha participates in shaping the peripheral T cell repertoire. J Exp Med. 1991;174:639-48 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 12.1 Monoclonal Antibody (6D6.6)

Catalog # :

TCR1764

Quantity :

200 ug

Price :

US 491.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: 1:100

Species :

Human, Rat

Clone :

6D6.6

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V alpha 12.1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: 1:100

Aliases :

TCRVA; TCRVA 12.1; V alpha 12.1; V alpha-12.1 TCR

more info or order :

Invitrogen product webpage