TCR V delta 2 Monoclonal Antibody (15D) | Invitrogen TCR1732 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V delta 2 Monoclonal Antibody (15D)

catalog :

TCR1732

quantity :

200 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

15D

reactivity :

African green monkey, human, chimpanzee, fruit fly , rhesus macaque

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
flow cytometry; rhesus macaque	Frencher J, Shen H, Yan L, Wilson J, Freitag N, Rizzo A, et al. HMBPP-deficient Listeria mutant immunization alters pulmonary/systemic responses, effector functions, and memory polarization of VÎ³2VÎ´2 T cells. J Leukoc Biol. 2014;96:957-67 pubmed publisher
flow cytometry; African green monkey flow cytometry; chimpanzee	Hodara V, Parodi L, Chavez D, Smith L, Lanford R, Giavedoni L. Characterization of ??T cells in naïve and HIV-infected chimpanzees and their responses to T-cell activators in vitro. J Med Primatol. 2014;43:258-71 pubmed publisher
flow cytometry; rhesus macaque	Chen C, Yao S, Huang D, Wei H, Sicard H, Zeng G, et al. Phosphoantigen/IL2 expansion and differentiation of V?2V?2 T cells increase resistance to tuberculosis in nonhuman primates. PLoS Pathog. 2013;9:e1003501 pubmed publisher
flow cytometry; rhesus macaque	Didier E, Sugimoto C, Bowers L, Khan I, Kuroda M. Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta). Immun Ageing. 2012;9:25 pubmed publisher
flow cytometry; rhesus macaque	Ryan Payseur B, Frencher J, Shen L, Chen C, Huang D, Chen Z. Multieffector-functional immune responses of HMBPP-specific V?2V?2 T cells in nonhuman primates inoculated with Listeria monocytogenes ?actA prfA*. J Immunol. 2012;189:1285-93 pubmed publisher
flow cytometry; rhesus macaque	Harris L, Klatt N, Vinton C, Briant J, Tabb B, Ladell K, et al. Mechanisms underlying ?? T-cell subset perturbations in SIV-infected Asian rhesus macaques. Blood. 2010;116:4148-57 pubmed publisher
western blot; fruit fly	Wei H, Huang D, Lai X, Chen M, Zhong W, Wang R, et al. Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vgamma2Vdelta 2 TCR. J Immunol. 2008;181:4798-806 pubmed
flow cytometry; African green monkey	Sicard H, Ingoure S, Luciani B, Serraz C, Fournie J, Bonneville M, et al. In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model. J Immunol. 2005;175:5471-80 pubmed
flow cytometry; African green monkey; fig 1	Casetti R, Perretta G, Taglioni A, Mattei M, Colizzi V, Dieli F, et al. Drug-induced expansion and differentiation of V gamma 9V delta 2 T cells in vivo: the role of exogenous IL-2. J Immunol. 2005;175:1593-8 pubmed
flow cytometry; human	Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
	Barber Axthelm I, Wragg K, Esterbauer R, Amarasena T, Barber Axthelm V, Wheatley A, et al. Phenotypic and functional characterization of pharmacologically expanded Vγ9Vδ2 T cells in pigtail macaques. iScience. 2023;26:106269 pubmed publisher
	Albertsson A, Zhang X, Vontell R, Bi D, Bronson R, Supramaniam V, et al. γδ T Cells Contribute to Injury in the Developing Brain. Am J Pathol. 2018;188:757-767 pubmed publisher
	Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed publisher
	Zhou D, Lai X, Shen Y, Sehgal P, Shen L, Simon M, et al. Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys. J Virol. 2003;77:2998-3006 pubmed
	Miossec C, Faure F, Ferradini L, Roman Roman S, Jitsukawa S, Ferrini S, et al. Further analysis of the T cell receptor gamma/delta+ peripheral lymphocyte subset. The V delta 1 gene segment is expressed with either C alpha or C delta. J Exp Med. 1990;171:1171-88 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V delta 2 Monoclonal Antibody (15D)

Catalog # :

TCR1732

Quantity :

200 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: 1:100

Species :

Human

Clone :

15D

Isotype :

IgG1

Storage :

-20 C

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V delta 2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: 1:100

more info or order :

Invitrogen product webpage