TCR V gamma 9 Monoclonal Antibody (7A5) | Invitrogen TCR1720 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V gamma 9 Monoclonal Antibody (7A5)

catalog :

TCR1720

quantity :

200 ug

price :

US 440.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7A5

reactivity :

African green monkey, human, fruit fly , rhesus macaque

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rhesus macaque; 1:10	Chen C, Yao S, Huang D, Wei H, Sicard H, Zeng G, et al. Phosphoantigen/IL2 expansion and differentiation of V?2V?2 T cells increase resistance to tuberculosis in nonhuman primates. PLoS Pathog. 2013;9:e1003501 pubmed publisher
blocking or activating experiments; human	Di Carlo E, Bocca P, Emionite L, Cilli M, Cipollone G, Morandi F, et al. Mechanisms of the antitumor activity of human V?9V?2 T cells in combination with zoledronic acid in a preclinical model of neuroblastoma. Mol Ther. 2013;21:1034-43 pubmed publisher
flow cytometry; rhesus macaque	Ryan Payseur B, Frencher J, Shen L, Chen C, Huang D, Chen Z. Multieffector-functional immune responses of HMBPP-specific V?2V?2 T cells in nonhuman primates inoculated with Listeria monocytogenes ?actA prfA*. J Immunol. 2012;189:1285-93 pubmed publisher
blocking or activating experiments; human	Morandi F, Prigione I, Airoldi I. Human TCR??+ T cells represent a novel target for IL-27 activity. Eur J Immunol. 2012;42:1547-52 pubmed publisher
flow cytometry; African green monkey	Yao S, Huang D, Chen C, Halliday L, Zeng G, Wang R, et al. Differentiation, distribution and gammadelta T cell-driven regulation of IL-22-producing T cells in tuberculosis. PLoS Pathog. 2010;6:e1000789 pubmed publisher
ELISA; human	Prigione I, Benvenuto F, Bocca P, Battistini L, Uccelli A, Pistoia V. Reciprocal interactions between human mesenchymal stem cells and gammadelta T cells or invariant natural killer T cells. Stem Cells. 2009;27:693-702 pubmed publisher
flow cytometry; African green monkey	Gong G, Shao L, Wang Y, Chen C, Huang D, Yao S, et al. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood. 2009;113:837-45 pubmed publisher
western blot; fruit fly	Wei H, Huang D, Lai X, Chen M, Zhong W, Wang R, et al. Definition of APC presentation of phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate to Vgamma2Vdelta 2 TCR. J Immunol. 2008;181:4798-806 pubmed
flow cytometry; human	Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
immunocytochemistry; human	Hewitt R, Lissina A, Green A, Slay E, Price D, Sewell A. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clin Exp Immunol. 2005;139:101-11 pubmed
flow cytometry; human	Green A, Lissina A, Hutchinson S, Hewitt R, Temple B, James D, et al. Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin. Clin Exp Immunol. 2004;136:472-82 pubmed
	Beatson R, Parente Pereira A, Halim L, Cozzetto D, Hull C, Whilding L, et al. TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer. Cell Rep Med. 2021;2:100473 pubmed publisher
	Jungbluth A, Frosina D, Fayad M, Pulitzer M, Dogan A, Busam K, et al. Immunohistochemical Detection of γ/δ T Lymphocytes in Formalin-fixed Paraffin-embedded Tissues. Appl Immunohistochem Mol Morphol. 2019;27:581-583 pubmed publisher
	Ali Z, Yan L, Plagman N, Reichenberg A, Hintz M, Jomaa H, et al. Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits. J Immunol. 2009;183:5407-17 pubmed publisher
	Zhou D, Lai X, Shen Y, Sehgal P, Shen L, Simon M, et al. Inhibition of adaptive Vgamma2Vdelta2+ T-cell responses during active mycobacterial coinfection of simian immunodeficiency virus SIVmac-infected monkeys. J Virol. 2003;77:2998-3006 pubmed
	Hviid L, Kurtzhals J, Adabayeri V, Loizon S, Kemp K, Goka B, et al. Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria. Infect Immun. 2001;69:3190-6 pubmed
	Weidmann E, Hinz T, Klein S, Schui D, Harder S, Kriener S, et al. Cytotoxic hepatosplenic gammadelta T-cell lymphoma following acute myeloid leukemia bearing two distinct gamma chains of the T-cell receptor. Biologic and clinical features. Haematologica. 2000;85:1024-31 pubmed
	Li B, Bassiri H, Rossman M, Kramer P, Eyuboglu A, Torres M, et al. Involvement of the Fas/Fas ligand pathway in activation-induced cell death of mycobacteria-reactive human gamma delta T cells: a mechanism for the loss of gamma delta T cells in patients with pulmonary tuberculosis. J Immunol. 1998;161:1558-67 pubmed
	Kabelitz D, Ackermann T, Hinz T, Davodeau F, Band H, Bonneville M, et al. New monoclonal antibody (23D12) recognizing three different V gamma elements of the human gamma delta T cell receptor. 23D12+ cells comprise a major subpopulation of gamma delta T cells in postnatal thymus. J Immunol. 1994;152:3128-36 pubmed
	Kabelitz D, Bender A, Schondelmaier S, da Silva Lobo M, Janssen O. Human cytotoxic lymphocytes. V. Frequency and specificity of gamma delta+ cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells. J Immunol. 1990;145:2827-32 pubmed
	Hohlfeld R, Engel A, Ii K, Harper M. Polymyositis mediated by T lymphocytes that express the gamma/delta receptor. N Engl J Med. 1991;324:877-81 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V gamma 9 Monoclonal Antibody (7A5)

Catalog # :

TCR1720

Quantity :

200 ug

Price :

US 440.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: 2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, Neutralization: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: 1:100

Species :

Human, Non-human primate

Clone :

7A5

Isotype :

IgG1

Storage :

-20 C

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR Vgamma9

Format :

Liquid

Applications w/Dilutions :

more info or order :

Invitrogen product webpage