TCR V alpha 2 Monoclonal Antibody (F1) | Invitrogen TCR1663 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V alpha 2 Monoclonal Antibody (F1)

catalog :

TCR1663

quantity :

200 ug

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Idali F, Wahlstrom J, Dahlberg B, Khademi M, Olsson T, Eklund A, et al. Altered expression of T cell immunoglobulin-mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis. Respir Res. 2009;10:42 pubmed publisher
immunohistochemistry; human	Maccalli C, Nonaka D, Piris A, Pende D, Rivoltini L, Castelli C, et al. NKG2D-mediated antitumor activity by tumor-infiltrating lymphocytes and antigen-specific T-cell clones isolated from melanoma patients. Clin Cancer Res. 2007;13:7459-68 pubmed
western blot; human	Thomas S, Xue S, Cesco Gaspere M, San José E, Hart D, Wong V, et al. Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells. J Immunol. 2007;179:5803-10 pubmed
immunohistochemistry; human	Vonderheid E, Boselli C, Conroy M, Casaus L, Espinoza L, Venkataramani P, et al. Evidence for restricted Vbeta usage in the leukemic phase of cutaneous T cell lymphoma. J Invest Dermatol. 2005;124:651-61 pubmed
	Carter J, Preall J, Atwal G. Bayesian Inference of Allelic Inclusion Rates in the Human T Cell Receptor Repertoire. Cell Syst. 2019;9:475-482.e4 pubmed publisher
	Xu B, Sakkas L, Goldman B, Jeevanandam V, Gaughan J, Oleszak E, et al. Identical alpha-chain T-cell receptor transcripts are present on T cells infiltrating coronary arteries of human cardiac allografts with chronic rejection. Cell Immunol. 2003;225:75-90 pubmed
	El Shabrawi Caelen L, Cerroni L, Medeiros L, McCalmont T. Hypopigmented mycosis fungoides: frequent expression of a CD8+ T-cell phenotype. Am J Surg Pathol. 2002;26:450-7 pubmed
	Korhonen M, Ormio M, Burgeson R, Virtanen I, Savilahti E. Unaltered distribution of laminins, fibronectin, and tenascin in celiac intestinal mucosa. J Histochem Cytochem. 2000;48:1011-20 pubmed
	Rantala I, Collin P, Holm K, Kainulainen H, Mustonen J, Maki M. Small bowel T cells, HLA class II antigen DR, and GroEL stress protein in IgA nephropathy. Kidney Int. 1999;55:2274-80 pubmed
	Sano S, Matsui Y, Itami S, Yoshikawa K. Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome. Clin Exp Immunol. 1998;113:190-7 pubmed
	Zaremba S, Barzaga E, Zhu M, Soares N, Tsang K, Schlom J. Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997;57:4570-7 pubmed
	Baca Estrada M, Wong D, Croitoru K. Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol. 1995;99:398-403 pubmed
	Janson C, Tehrani M, Mellstedt H, Wigzell H. Anti-idiotypic monoclonal antibody to a T-cell chronic lymphatic leukemia. Characterization of the antibody, in vitro effector functions and results of therapy. Cancer Immunol Immunother. 1989;28:225-32 pubmed
	O Grady J, Krajewski A, Ramage E. Demonstration of clonality in T-cell lymphoma using an anti-T-cell receptor variable region antibody panel. Histopathology. 1990;17:553-6 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V alpha 2 Monoclonal Antibody (F1)

Catalog # :

TCR1663

Quantity :

200 ug

Price :

US 491.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent

Species :

Human, Non-human primate

Clone :

Isotype :

IgG2a

Storage :

-20 C

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V alpha-2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent

Aliases :

TCRVA; TCRVA2; V alpha 2; V alpha-2 TCR; Va 2; Va2; Valpha 2; Valpha2

more info or order :

Invitrogen product webpage