TCR V beta 12 Monoclonal Antibody (S511) | Invitrogen TCR1654 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 12 Monoclonal Antibody (S511)

catalog :

TCR1654

quantity :

200 ug

price :

US 491.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

S511

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse	Mosenson J, Zloza A, Nieland J, Garrett Mayer E, Eby J, Huelsmann E, et al. Mutant HSP70 reverses autoimmune depigmentation in vitiligo. Sci Transl Med. 2013;5:174ra28 pubmed publisher
immunohistochemistry; mouse	Mehrotra S, Al Khami A, Klarquist J, Husain S, Naga O, Eby J, et al. A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice. J Immunol. 2012;189:1627-38 pubmed publisher
flow cytometry; human	Eberl M, Roberts G, Meuter S, Williams J, Topley N, Moser B. A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections. PLoS Pathog. 2009;5:e1000308 pubmed publisher
flow cytometry; human	Futagbi G, Welbeck J, Tetteh J, Hviid L, Akanmori B. Selective activation of TCR-gammadelta+ cells in endemic Burkitt's lymphoma. Malar J. 2007;6:69 pubmed
immunohistochemistry; human	Vonderheid E, Boselli C, Conroy M, Casaus L, Espinoza L, Venkataramani P, et al. Evidence for restricted Vbeta usage in the leukemic phase of cutaneous T cell lymphoma. J Invest Dermatol. 2005;124:651-61 pubmed
immunocytochemistry; human	Hewitt R, Lissina A, Green A, Slay E, Price D, Sewell A. The bisphosphonate acute phase response: rapid and copious production of proinflammatory cytokines by peripheral blood gd T cells in response to aminobisphosphonates is inhibited by statins. Clin Exp Immunol. 2005;139:101-11 pubmed
	Green A, Lissina A, Hutchinson S, Hewitt R, Temple B, James D, et al. Recognition of nonpeptide antigens by human V gamma 9V delta 2 T cells requires contact with cells of human origin. Clin Exp Immunol. 2004;136:472-82 pubmed
	Zadeh H, Nalbant A, Park K. Large-scale early in vitro response to actinobacillus actinomycetemcomitans suggests superantigenic activation of T-cells. J Dent Res. 2001;80:356-62 pubmed
	Eick A, Larned J, Jason J. Effects of HIV-1 peptides on T-cell receptor variable beta chain families. Hum Immunol. 2000;61:993-1000 pubmed
	Soudeyns H, Champagne P, Holloway C, Silvestri G, Ringuette N, Samson J, et al. Transient T cell receptor beta-chain variable region-specific expansions of CD4+ and CD8+ T cells during the early phase of pediatric human immunodeficiency virus infection: characterization of expanded cell populations by T cell receptor phenotyping. J Infect Dis. 2000;181:107-20 pubmed
	Cipriani B, Borsellino G, Poccia F, Placido R, Tramonti D, Bach S, et al. Activation of C-C beta-chemokines in human peripheral blood gammadelta T cells by isopentenyl pyrophosphate and regulation by cytokines. Blood. 2000;95:39-47 pubmed
	Sano S, Matsui Y, Itami S, Yoshikawa K. Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome. Clin Exp Immunol. 1998;113:190-7 pubmed
	Lamphear J, Bohach G, Rich R. Structural dichotomy of staphylococcal enterotoxin C superantigens leading to MHC class II-independent activation of T lymphocytes. J Immunol. 1998;160:2107-14 pubmed
	Zaremba S, Barzaga E, Zhu M, Soares N, Tsang K, Schlom J. Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997;57:4570-7 pubmed
	Baca Estrada M, Wong D, Croitoru K. Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol. 1995;99:398-403 pubmed
	Bigler R, Fisher D, Wang C, Rinnooy Kan E, Kunkel H. Idiotype-like molecules on cells of a human T cell leukemia. J Exp Med. 1983;158:1000-5 pubmed
	Posnett D, Wang C, Friedman S. Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody. Proc Natl Acad Sci U S A. 1986;83:7888-92 pubmed
	Poppema S, Hepperle B. Restricted V gene usage in T-cell lymphomas as detected by anti-T-cell receptor variable region reagents. Am J Pathol. 1991;138:1479-84 pubmed
	Waller E, Sen Majumdar A, Kamel O, Hansteen G, Schick M, Weissman I. Human T-cell development in SCID-hu mice: staphylococcal enterotoxins induce specific clonal deletions, proliferation, and anergy. Blood. 1992;80:3144-56 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 12 Monoclonal Antibody (S511)

Catalog # :

TCR1654

Quantity :

200 ug

Price :

US 491.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Species :

Human

Clone :

S511

Isotype :

IgG2b

Storage :

-20 C

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V beta 12

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Aliases :

T cell receptor beta chain; T cell receptor beta locus; TCRB; TCRbeta; Tib; TRB; TRB@

more info or order :

Invitrogen product webpage