TCR V beta 8a Monoclonal Antibody (I6G8) | Invitrogen TCR1648 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR V beta 8a Monoclonal Antibody (I6G8)

catalog :

TCR1648

quantity :

200 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

I6G8

reactivity :

African green monkey, human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
flow cytometry; African green monkey	Gong G, Shao L, Wang Y, Chen C, Huang D, Yao S, et al. Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection. Blood. 2009;113:837-45 pubmed publisher
immunohistochemistry; human	Vonderheid E, Boselli C, Conroy M, Casaus L, Espinoza L, Venkataramani P, et al. Evidence for restricted Vbeta usage in the leukemic phase of cutaneous T cell lymphoma. J Invest Dermatol. 2005;124:651-61 pubmed
	Zadeh H, Nalbant A, Park K. Large-scale early in vitro response to actinobacillus actinomycetemcomitans suggests superantigenic activation of T-cells. J Dent Res. 2001;80:356-62 pubmed
	Raulf Heimsoth M, Merget R, Rihs H, Föhring M, Liebers V, Gellert B, et al. T-cell receptor repertoire expression in workers with occupational asthma due to platinum salt. Eur Respir J. 2000;16:871-8 pubmed
	Mugnaini E, Egeland T, Spurkland A, Brinchmann J. The T cell receptor repertoire of CD8+CD28- T lymphocytes is dominated by expanded clones that persist over time. Clin Exp Immunol. 1999;117:298-303 pubmed
	Sano S, Matsui Y, Itami S, Yoshikawa K. Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome. Clin Exp Immunol. 1998;113:190-7 pubmed
	Zaremba S, Barzaga E, Zhu M, Soares N, Tsang K, Schlom J. Identification of an enhancer agonist cytotoxic T lymphocyte peptide from human carcinoembryonic antigen. Cancer Res. 1997;57:4570-7 pubmed
	Baca Estrada M, Wong D, Croitoru K. Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol. 1995;99:398-403 pubmed
	Poppema S, Hepperle B. Restricted V gene usage in T-cell lymphomas as detected by anti-T-cell receptor variable region reagents. Am J Pathol. 1991;138:1479-84 pubmed
	Waller E, Sen Majumdar A, Kamel O, Hansteen G, Schick M, Weissman I. Human T-cell development in SCID-hu mice: staphylococcal enterotoxins induce specific clonal deletions, proliferation, and anergy. Blood. 1992;80:3144-56 pubmed

product information

Product Type :

Antibody

Product Name :

TCR V beta 8a Monoclonal Antibody (I6G8)

Catalog # :

TCR1648

Quantity :

200 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: Assay-dependent

Species :

Human, Non-human primate

Clone :

I6G8

Isotype :

IgG2b

Storage :

-20 C

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR V beta 8

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent, Western Blot: Assay-dependent

Aliases :

T cell receptor beta locus; TCRB; TRB; TRB@

more info or order :

Invitrogen product webpage