TRAC Monoclonal Antibody (3A8) | Invitrogen TCR1145 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TRAC Monoclonal Antibody (3A8)

catalog :

TCR1145

quantity :

200 ug

price :

US 471.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3A8

reactivity :

fission yeast, human

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; fig 1	Feige M, Behnke J, Mittag T, Hendershot L. Dimerization-dependent folding underlies assembly control of the clonotypic Î±Î²T cell receptor chains. J Biol Chem. 2015;290:26821-31 pubmed publisher
flow cytometry; human immunohistochemistry; human; 1:100 western blot; human	Beham A, Puellmann K, Laird R, Fuchs T, Streich R, Breysach C, et al. A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis. PLoS Pathog. 2011;7:e1002375 pubmed publisher
flow cytometry; fission yeast	Aggen D, Chervin A, Insaidoo F, Piepenbrink K, Baker B, Kranz D. Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors. Protein Eng Des Sel. 2011;24:361-72 pubmed publisher
flow cytometry; human	RICHMAN S, Aggen D, Dossett M, Donermeyer D, Allen P, Greenberg P, et al. Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragments. Mol Immunol. 2009;46:902-16 pubmed publisher
immunohistochemistry; human	Buri C, Burri P, Bähler P, Straumann A, Müller Schenker B, Birrer S, et al. Cytotoxic T cells are preferentially activated in the duodenal epithelium from patients with florid coeliac disease. J Pathol. 2005;206:178-85 pubmed
	Feige M, Hendershot L. Quality control of integral membrane proteins by assembly-dependent membrane integration. Mol Cell. 2013;51:297-309 pubmed publisher
	Carrasco Y, Navarro M, Toribio M. A role for the cytoplasmic tail of the pre-T cell receptor (TCR) alpha chain in promoting constitutive internalization and degradation of the pre-TCR. J Biol Chem. 2003;278:14507-13 pubmed
	Demotte N, Colau D, Ottaviani S, Godelaine D, Van Pel A, Boon T, et al. A reversible functional defect of CD8+ T lymphocytes involving loss of tetramer labeling. Eur J Immunol. 2002;32:1688-97 pubmed
	Appel H, Gauthier L, Pyrdol J, Wucherpfennig K. Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells. J Biol Chem. 2000;275:312-21 pubmed
	Sano S, Matsui Y, Itami S, Yoshikawa K. Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome. Clin Exp Immunol. 1998;113:190-7 pubmed

product information

Product Type :

Antibody

Product Name :

TRAC Monoclonal Antibody (3A8)

Catalog # :

TCR1145

Quantity :

200 ug

Price :

US 471.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent

Species :

Human

Clone :

3A8

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The antigen-specific T cell receptor (TCR) is composed of either alpha and beta subunit, or gamma and delta subunit. Majority of T cells present in the blood, lymph and secondary lymphoid organs express TCR alpha/beta heterodimers, whereas the T cells expressing TCR gamma/delta heterodimers are localized mainly in epithelial tissues and at the sites of infection. The subunits of TCR heterodimers are covalently bonded and in the endoplasmic reticulum they associate with CD3 subunits to form functional TCR-CD3 complex. Lack of expression of any of the chains is sufficient to stop cell surface expression.

Immunogen :

Human TCR alpha chain constant region

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunohistochemistry (Paraffin): 1:10-1:100, Immunoprecipitation: Assay-dependent

Aliases :

IMD7; T-cell receptor; T-cell receptor alpha constant; TCRA; TRA; TRAC; TRCA

more info or order :

Invitrogen product webpage