TCR delta Monoclonal Antibody (TS-1) | Invitrogen TCR1055 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TCR delta Monoclonal Antibody (TS-1)

catalog :

TCR1055

quantity :

200 ug

price :

US 502.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TS-1

reactivity :

human

application :

immunohistochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human	Roy S, Ly D, Castro C, Li N, Hawk A, Altman J, et al. Molecular Analysis of Lipid-Reactive VÎ´1 Î³Î´ T Cells Identified by CD1c Tetramers. J Immunol. 2016;196:1933-42 pubmed publisher
flow cytometry; human; fig s1	Dimova T, Brouwer M, Gosselin F, Tassignon J, Leo O, Donner C, et al. Effector VÎ³9VÎ´2 T cells dominate the human fetal Î³Î´ T-cell repertoire. Proc Natl Acad Sci U S A. 2015;112:E556-65 pubmed publisher
flow cytometry; human	Donia M, Ellebaek E, Andersen M, Straten P, Svane I. Analysis of V?1 T cells in clinical grade melanoma-infiltrating lymphocytes. Oncoimmunology. 2012;1:1297-1304 pubmed
flow cytometry; human	Vermijlen D, Brouwer M, Donner C, Liesnard C, Tackoen M, Van Rysselberge M, et al. Human cytomegalovirus elicits fetal gammadelta T cell responses in utero. J Exp Med. 2010;207:807-21 pubmed publisher
flow cytometry; human	Agea E, Russano A, Bistoni O, Mannucci R, Nicoletti I, Corazzi L, et al. Human CD1-restricted T cell recognition of lipids from pollens. J Exp Med. 2005;202:295-308 pubmed
	Crespí C, Rosa Julià M, Munoz Saá I, Pérez Castellano M, Mila J, Matamoros N. Skewed inhibitory receptors expression in a TAP2-deficient patient. Immunol Lett. 2003;86:149-53 pubmed
	Hviid L, Kurtzhals J, Adabayeri V, Loizon S, Kemp K, Goka B, et al. Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria. Infect Immun. 2001;69:3190-6 pubmed
	Katoh A, Ohshima K, Kanda M, Haraoka S, Sugihara M, Suzumiya J, et al. Gastrointestinal T cell lymphoma: predominant cytotoxic phenotypes, including alpha/beta, gamma/delta T cell and natural killer cells. Leuk Lymphoma. 2000;39:97-111 pubmed
	Sano S, Matsui Y, Itami S, Yoshikawa K. Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sézary syndrome. Clin Exp Immunol. 1998;113:190-7 pubmed
	Poccia F, Boullier S, Lecoeur H, Cochet M, Poquet Y, Colizzi V, et al. Peripheral V gamma 9/V delta 2 T cell deletion and anergy to nonpeptidic mycobacterial antigens in asymptomatic HIV-1-infected persons. J Immunol. 1996;157:449-61 pubmed
	Kabelitz D, Ackermann T, Hinz T, Davodeau F, Band H, Bonneville M, et al. New monoclonal antibody (23D12) recognizing three different V gamma elements of the human gamma delta T cell receptor. 23D12+ cells comprise a major subpopulation of gamma delta T cells in postnatal thymus. J Immunol. 1994;152:3128-36 pubmed
	Wu Y, Tian W, Snider R, Rittershaus C, Rogers P, Lamanna L, et al. Signal transduction of gamma/delta T cell antigen receptor with a novel mitogenic anti-delta antibody. J Immunol. 1988;141:1476-9 pubmed
	Falini B, Flenghi L, Pileri S, Pelicci P, Fagioli M, Martelli M, et al. Distribution of T cells bearing different forms of the T cell receptor gamma/delta in normal and pathological human tissues. J Immunol. 1989;143:2480-8 pubmed
	Rivas A, Koide J, Cleary M, Engleman E. Evidence for involvement of the gamma, delta T cell antigen receptor in cytotoxicity mediated by human alloantigen-specific T cell clones. J Immunol. 1989;142:1840-6 pubmed
	Yeh C, Bulmer J, Hsi B, Tian W, Rittershaus C, Ip S. Monoclonal antibodies to T cell receptor gamma/delta complex react with human endometrial glandular epithelium. Placenta. 1990;11:253-61 pubmed
	Kabelitz D, Bender A, Schondelmaier S, da Silva Lobo M, Janssen O. Human cytotoxic lymphocytes. V. Frequency and specificity of gamma delta+ cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells. J Immunol. 1990;145:2827-32 pubmed
	Fisch P, Malkovsky M, Kovats S, Sturm E, Braakman E, Klein B, et al. Recognition by human V gamma 9/V delta 2 T cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science. 1990;250:1269-73 pubmed

product information

Product Type :

Antibody

Product Name :

TCR delta Monoclonal Antibody (TS-1)

Catalog # :

TCR1055

Quantity :

200 ug

Price :

US 502.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Species :

Human

Clone :

TS-1

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.

Immunogen :

Human TCR Vdelta1-Jdelta1

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-2 ug/test, Immunohistochemistry (Frozen): Assay-dependent, Immunoprecipitation: Assay-dependent, T-Cell Activation: Assay-dependent

Aliases :

CD3 antigen; CD3d antigen; OKT3

more info or order :

Invitrogen product webpage