Porcine IL-1 beta Recombinant Protein | Invitrogen RPIL1BI product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Porcine IL-1 beta Recombinant Protein

catalog :

RPIL1BI

quantity :

20µg

price :

296 USD

product information

Product Type :

Protein

Product Name :

Porcine IL-1 beta Recombinant Protein

Catalog # :

RPIL1BI

Quantity :

20µg

Price :

296 USD

Clonality :

Recombinant

Purity :

purified

Host :

Yeast

Reactivity :

Porcine

Applications :

Control: Assay Dependent, ELISA: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Porcine

Storage :

4° C

Description :

Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.

Format :

Lyophilized

Applications w/Dilutions :

Control: Assay Dependent, ELISA: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

IL-1 beta; catabolin; interleukin-1 beta; preinterleukin 1 beta; pro-interleukin-1-beta; IL-1beta