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protein

Human ATXN7L2 (aa 262-340) Control Fragment Recombinant Protein

RP-94399

100 uL

US 259.00

Human ATXN7L2 (aa 262-340) Control Fragment Recombinant Protein

RP-94399

100 uL

US 259.00

Recombinant

purified

Human

Blocking Assay: Assay-dependent, Control: Assay-dependent

Human

-20 C, Avoid Freeze/Thaw Cycles

SCA7 is an autosomal dominant neurodegenerative disorder characterized by ataxia and selective neuronal cell loss caused by the expansion of a translated CAG repeat encoding a polyglutamine tract in ataxin-7, which is the SCA7 gene product. Ataxin-7 is a nuclear protein that is expressed within neurons both affected and unaffected in SCA7 pathology with subcellular localization being variable depending upon the neuronal subtype. Polyglutamine expanded in ataxin-7 may carry out its pathogenic effects in the nucleus by altering the matrix-associated nuclear structure and/or by disrupting nucleolar function.ATXN7L2 (Ataxin-7-like protein 2) is a 722 amino acid protein that contains a SCA7 domain, which is highly conserved through all members of the ATXN7 gene family. The gene encoding ATXN7L2 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome.

Liquid

Blocking Assay: Assay-dependent, Control: Assay-dependent

2610528J18Rik; ataxin 7 like 2; ataxin 7-like 1; ataxin 7-like 2; ataxin-7-like protein 2; ATXN7L2; mFLJ00381 protein; RGD1307047