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protein

Human CEP78 (aa 279-369) Control Fragment Recombinant Protein

RP-92996

100 uL

US 259.00

Human CEP78 (aa 279-369) Control Fragment Recombinant Protein

RP-92996

100 uL

US 259.00

Recombinant

purified

Human

Blocking Assay: Assay-dependent, Control: Assay-dependent

Human

-20 C, Avoid Freeze/Thaw Cycles

This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients.

Liquid

Blocking Assay: Assay-dependent, Control: Assay-dependent

5730599I05Rik; C9orf81; centrosomal protein 78; centrosomal protein 78kDa; centrosomal protein of 78 kDa; Cep78; D030027P05; IP63