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protein

Human COMMD10 (aa 62-118) Control Fragment Recombinant Protein

RP-108056

100 uL

US 259.00

Human COMMD10 (aa 62-118) Control Fragment Recombinant Protein

RP-108056

100 uL

US 259.00

Recombinant

purified

Human

Blocking Assay: Assay-dependent, Control: Assay-dependent

Human

-20 C, Avoid Freeze/Thaw Cycles

The COMMD family represents a group of evolutionary conserved proteins that share a common COMM domain at their extreme C-terminus, which provides an interface for protein-protein interactions. COMMD10 (COMM domain containing 10), also known as PTD002 or HSPC305, is a 202 amino acid protein that belongs to the COMMD family and contains one COMM domain. The gene encoding COMMD10 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B.

Liquid

Blocking Assay: Assay-dependent, Control: Assay-dependent

2310003A05Rik; AU019438; COMM domain containing 10; COMM domain-containing protein 10; COMMD10; Down-regulated in W/WV mouse stomach 2; DRWMS2; HSPC305; mDRWMS2; PTD002