c-Kit Monoclonal Antibody (2B8), Alexa Fluor 647 | Invitrogen RM6221 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

c-Kit Monoclonal Antibody (2B8), Alexa Fluor 647

catalog :

RM6221

quantity :

1 mL

price :

US 319

clonality :

monoclonal

host :

rat

conjugate :

AF647

clone name :

2B8

reactivity :

mouse

application :

flow cytometry, immunohistochemistry - frozen section

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Di Siena S, Gimmelli R, Nori S, Barbagallo F, Campolo F, Dolci S, et al. Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury. Cell Death Dis. 2016;7:e2317 pubmed publisher
immunohistochemistry - frozen section; mouse	Taylor R, Patel S, Lin E, Butler B, Lake J, Newberry R, et al. Lymphotoxin-independent expression of TNF-related activation-induced cytokine by stromal cells in cryptopatches, isolated lymphoid follicles, and Peyer's patches. J Immunol. 2007;178:5659-67 pubmed

product information

Product Type :

Antibody

Product Name :

c-Kit Monoclonal Antibody (2B8), Alexa Fluor 647

Catalog # :

RM6221

Quantity :

1 mL

Price :

US 319

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: 0.1-0.25 µg / 1x10^6 cells

Species :

Mouse

Clone :

2B8

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.

Immunogen :

IL-3-dependent mast cells derived from normal bone marrow.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 0.1-0.25 µg / 1x10^6 cells

Aliases :

C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein, ckit