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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD11b Monoclonal Antibody (M1/70.15), PE-Texas Red
catalog :
RM2817
quantity :
500 uL
price :
US 508.00
clonality :
monoclonal
host :
rat
conjugate :
PE Texas Red
clone name :
M1/70.15
reactivity :
mouse
application :
flow cytometry
more info or order :
Invitrogen product webpage
citations: 16
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1a
Kim G, Das R, Goduni L, McClellan S, Hazlett L, Mahabeleshwar G. Kruppel-like Factor 6 Promotes Macrophage-mediated Inflammation by Suppressing B Cell Leukemia/Lymphoma 6 Expression. J Biol Chem. 2016;291:21271-21282 pubmed
Qiu J, Wu J, Chen W, Ruan Y, Mao J, Li S, et al. NOD1 deficiency ameliorates the progression of diabetic retinopathy by modulating bone marrow-retina crosstalk. Stem Cell Res Ther. 2024;15:38 pubmed publisher
Song H, Chen F, Park H, Han J, Ji H, Byun E, et al. Low-dose radiation therapy suppresses viral pneumonia by enhancing broad-spectrum anti-inflammatory responses via transforming growth factor-β production. Front Immunol. 2023;14:1182927 pubmed publisher
Wiedemann S, Trimigliozzi K, Dror E, Meier D, Molina Tijeras J, Rachid L, et al. The cephalic phase of insulin release is modulated by IL-1β. Cell Metab. 2022;34:991-1003.e6 pubmed publisher
Uhl F, Vanherle L, Matthes F, Meissner A. Therapeutic CFTR Correction Normalizes Systemic and Lung-Specific S1P Level Alterations Associated with Heart Failure. Int J Mol Sci. 2022;23: pubmed publisher
Becattini S, Littmann E, Seok R, Amoretti L, Fontana E, Wright R, et al. Enhancing mucosal immunity by transient microbiota depletion. Nat Commun. 2020;11:4475 pubmed publisher
JAISWAL A, Makhija S, Stahr N, Sandey M, Suryawanshi A, Mishra A. Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation. Immunobiology. 2020;225:151956 pubmed publisher
Wang L, Zhang H, Sun L, Gao W, Xiong Y, Ma A, et al. Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury. J Nanobiotechnology. 2020;18:38 pubmed publisher
Brykczynska U, Geigges M, Wiedemann S, Dror E, Böni Schnetzler M, Hess C, et al. Distinct Transcriptional Responses across Tissue-Resident Macrophages to Short-Term and Long-Term Metabolic Challenge. Cell Rep. 2020;30:1627-1643.e7 pubmed publisher
Keith J, Dong Q, Sorbara M, Becattini S, Sia J, Gjonbalaj M, et al. Impact of Antibiotic-Resistant Bacteria on Immune Activation and Clostridioides difficile Infection in the Mouse Intestine. Infect Immun. 2020;88: pubmed publisher
Kim G, Ng H, Patel N, Mahabeleshwar G. Kruppel-like factor 6 and miR-223 signaling axis regulates macrophage-mediated inflammation. FASEB J. 2019;33:10902-10915 pubmed publisher
Raso A, Dirkx E, Philippen L, Fernández Celis A, De Majo F, Sampaio Pinto V, et al. Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure. Mol Ther. 2019;27:584-599 pubmed publisher
Theurich S, Tsaousidou E, Hanssen R, Lempradl A, Mauer J, Timper K, et al. IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis. Cell Metab. 2017;26:171-184.e6 pubmed publisher
Becattini S, Littmann E, Carter R, Kim S, Morjaria S, Ling L, et al. Commensal microbes provide first line defense against Listeria monocytogenes infection. J Exp Med. 2017;214:1973-1989 pubmed publisher
Rak G, Osborne L, Siracusa M, Kim B, Wang K, Bayat A, et al. IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing. J Invest Dermatol. 2016;136:487-496 pubmed publisher
Sanfilippo A, Furuya Y, Roberts S, Salmon S, Metzger D. Allergic Lung Inflammation Reduces Tissue Invasion and Enhances Survival from Pulmonary Pneumococcal Infection in Mice, Which Correlates with Increased Expression of Transforming Growth Factor β1 and SiglecF(low) Alveolar Macrophages. Infect Immun. 2015;83:2976-83 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD11b Monoclonal Antibody (M1/70.15), PE-Texas Red
Catalog # :
RM2817
Quantity :
500 uL
Price :
US 508.00
Clonality :
Monoclonal
Purity :
purified
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: Assay-dependent
Species :
Mouse
Clone :
M1/70.15
Isotype :
IgG2b
Storage :
4 C
Description :
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.
Immunogen :
C57BL/10 splenic T cells and concanavalin A stimulated C57BL/10 splenocytes
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-dependent
Aliases :
antigen CD11b (p170); antigen CD11b (p170); macrophage antigen alpha polypeptide; CD11 antigen-like family member B; CD11b; CD11B (p170); CD11b/CD18; cell surface glycoprotein MAC-1 alpha subunit; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; complement component receptor 3 alpha-a; complement receptor type 3; CR3; CR-3 alpha chain; CR3A; F730045J24Rik; integrin alpha M; integrin alpha-M; integrin subunit alpha M; integrin, alpha M; integrin, alpha M (complement component 3 receptor 3 subunit); ITGAM; Leukocyte adhesion receptor MO1; leukocyte integrin alpha-M chain; LOC100351865; Ly-40; MAC1; Mac-1; Mac-1 alpha; Mac-1 alpha (Mac1A); MAC-1 alpha subunit; MAC1A; Mac-1a; macrophage antigen alpha; macrophage antigen alpha polypeptide; MGC117044; MO1A; Neutrophil adherence receptor; neutrophil adherence receptor alpha-M subunit; SLEB6; unnamed protein product
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA