CD45R Monoclonal Antibody (RA3-6B2), Pacific Orange | Invitrogen RM2630TR product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45R Monoclonal Antibody (RA3-6B2), Pacific Orange

catalog :

RM2630TR

quantity :

25 tests

price :

US 147.00

clonality :

monoclonal

host :

rat

conjugate :

pacific orange

clone name :

RA3-6B2

reactivity :

mouse

application :

flow cytometry

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse	Smolarchuk C, Zhu L, Chan W, Anderson C. T cells generated in the absence of a thoracic thymus fail to establish homeostasis. Eur J Immunol. 2014;44:2263-73 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45R Monoclonal Antibody (RA3-6B2), Pacific Orange

Catalog # :

RM2630TR

Quantity :

25 tests

Price :

US 147.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay Dependent

Species :

Mouse

Clone :

RA3-6B2

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

Immunogen :

exon A-specific epitope on CD45

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent

Aliases :

B220, CD45R, Cd45, Ly-5, Lyt-4, T200, Cluster designation 45R