This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD45R Monoclonal Antibody (RA3-6B2), PE
catalog :
RM2604
quantity :
500µL
price :
US 144
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
RA3-6B2
reactivity :
mouse
application :
flow cytometry
citations: 26
| Published Application/Species/Sample/Dilution | Reference |
|---|---|
| |
| Lu M, Tayu R, Ikawa T, Masuda K, Matsumoto I, Mugishima H, et al. The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRbeta chains than fetal progenitors. J Immunol. 2005;175:5848-56 pubmed
|
| Noel J, Guo X, Wells Byrum D, Schwemberger S, Caldwell C, Ogle C. Effect of thermal injury on splenic myelopoiesis. Shock. 2005;23:115-22 pubmed
|
| Chen B, Cui X, Sempowski G, Chao N. Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. Exp Hematol. 2003;31:953-8 pubmed
|
| Yamasaki M, Chujo H, Hirao A, Koyanagi N, Okamoto T, Tojo N, et al. Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid. J Nutr. 2003;133:784-8 pubmed
|
| Cabatingan M, Schmidt M, Sen R, Woodland R. Naive B lymphocytes undergo homeostatic proliferation in response to B cell deficit. J Immunol. 2002;169:6795-805 pubmed
|
| Street S, Trapani J, MacGregor D, Smyth M. Suppression of lymphoma and epithelial malignancies effected by interferon gamma. J Exp Med. 2002;196:129-34 pubmed
|
| Prasad S, Goodnow C. Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo. Int Immunol. 2002;14:677-84 pubmed
|
| Sonoda K, Taniguchi M, Stein Streilein J. Long-term survival of corneal allografts is dependent on intact CD1d-reactive NKT cells. J Immunol. 2002;168:2028-34 pubmed
|
| Ohmura K, Kawamoto H, Lu M, Ikawa T, Ozaki S, Nakao K, et al. Immature multipotent hemopoietic progenitors lacking long-term bone marrow-reconstituting activity in the aorta-gonad-mesonephros region of murine day 10 fetuses. J Immunol. 2001;166:3290-6 pubmed
|
| Izeradjene K, Revillard J, Genestier L. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells. Int Immunol. 2001;13:85-93 pubmed
|
| Smyth M, Thia K, Street S, MacGregor D, Godfrey D, Trapani J. Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma. J Exp Med. 2000;192:755-60 pubmed
|
| Lepault F, Gagnerault M. Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J Immunol. 2000;164:240-7 pubmed
|
| Sonoda K, Exley M, Snapper S, Balk S, Stein Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med. 1999;190:1215-26 pubmed
|
| Ohmura K, Kawamoto H, Fujimoto S, Ozaki S, Nakao K, Katsura Y. Emergence of T, B, and myeloid lineage-committed as well as multipotent hemopoietic progenitors in the aorta-gonad-mesonephros region of day 10 fetuses of the mouse. J Immunol. 1999;163:4788-95 pubmed
|
| Kawamoto H, Ohmura K, Fujimoto S, Katsura Y. Emergence of T cell progenitors without B cell or myeloid differentiation potential at the earliest stage of hematopoiesis in the murine fetal liver. J Immunol. 1999;162:2725-31 pubmed
|
| Batteux F, Tourneur L, Trebeden H, Charreire J, Chiocchia G. Gene therapy of experimental autoimmune thyroiditis by in vivo administration of plasmid DNA coding for Fas ligand. J Immunol. 1999;162:603-8 pubmed
|
| Moritz D, Rodewald H, Gheyselinck J, Klemenz R. The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. J Immunol. 1998;161:4866-74 pubmed
|
| Rathmell J, Fournier S, Weintraub B, Allison J, Goodnow C. Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells. J Exp Med. 1998;188:651-9 pubmed
|
| Guttormsen H, Wetzler L, Finberg R, Kasper D. Immunologic memory induced by a glycoconjugate vaccine in a murine adoptive lymphocyte transfer model. Infect Immun. 1998;66:2026-32 pubmed
|
| Akkaraju S, Canaan K, Goodnow C. Self-reactive B cells are not eliminated or inactivated by autoantigen expressed on thyroid epithelial cells. J Exp Med. 1997;186:2005-12 pubmed
|
| Cook M, Basten A, Fazekas de St Groth B. Outer periarteriolar lymphoid sheath arrest and subsequent differentiation of both naive and tolerant immunoglobulin transgenic B cells is determined by B cell receptor occupancy. J Exp Med. 1997;186:631-43 pubmed
|
| Barrat F, Lesourd B, Louise A, Boulouis H, Vincent Naulleau S, Thibault D, et al. Surface antigen expression in spleen cells of C57B1/6 mice during ageing: influence of sex and parity. Clin Exp Immunol. 1997;107:593-600 pubmed
|
| Hattori N, Kawamoto H, Katsura Y. Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells. J Exp Med. 1996;184:1901-8 pubmed
|
| Pear W, Aster J, Scott M, Hasserjian R, Soffer B, Sklar J, et al. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med. 1996;183:2283-91 pubmed
|
| Mixter P, Russell J, Durie F, Budd R. Decreased CD4-CD8- TCR-alpha beta + cells in lpr/lpr mice lacking beta 2-microglobulin. J Immunol. 1995;154:2063-74 pubmed
|
product information
Product Type :
Antibody
Product Name :
CD45R Monoclonal Antibody (RA3-6B2), PE
Catalog # :
RM2604
Quantity :
500µL
Price :
US 144
Clonality :
Monoclonal
Purity :
purified
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: Assay Dependent
Species :
Mouse
Clone :
RA3-6B2
Isotype :
IgG2a, kappa
Storage :
4° C
Description :
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.
Immunogen :
exon A-specific epitope on CD45
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay Dependent
Aliases :
B220, CD45R, Cd45, Ly-5, Lyt-4, T200, Cluster designation 45R
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
questions and comments