IL-10 Monoclonal Antibody (JES3-9D7), FITC | Invitrogen RHCIL1001 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IL-10 Monoclonal Antibody (JES3-9D7), FITC

catalog :

RHCIL1001

quantity :

1 mL

price :

US 338.00

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

JES3-9D7

reactivity :

human

application :

ELISA, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1 ug/ml; fig 3	Konry T, Dominguez Villar M, Baecher Allan C, Hafler D, Yarmush M. Droplet-based microfluidic platforms for single T cell secretion analysis of IL-10 cytokine. Biosens Bioelectron. 2011;26:2707-10 pubmed publisher
flow cytometry; human; fig 3	Della Bella S, Giannelli S, Taddeo A, Presicce P, Villa M. Application of six-color flow cytometry for the assessment of dendritic cell responses in whole blood assays. J Immunol Methods. 2008;339:153-64 pubmed publisher
flow cytometry; human	Van Damme N, De Keyser F, Demetter P, Baeten D, Mielants H, Verbruggen G, et al. The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome. Clin Exp Immunol. 2001;125:383-90 pubmed
ELISA; human	Salgame P, Abrams J, Clayberger C, Goldstein H, Convit J, Modlin R, et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science. 1991;254:279-82 pubmed
ELISA; human; fig 1	Yssel H, de Waal Malefyt R, Roncarolo M, Abrams J, Lahesmaa R, Spits H, et al. IL-10 is produced by subsets of human CD4+ T cell clones and peripheral blood T cells. J Immunol. 1992;149:2378-84 pubmed

product information

Product Type :

Antibody

Product Name :

IL-10 Monoclonal Antibody (JES3-9D7), FITC

Catalog # :

RHCIL1001

Quantity :

1 mL

Price :

US 338.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Human

Applications :

Flow Cytometry: 5 uL / 1x10^6 cells

Species :

Human

Clone :

JES3-9D7

Isotype :

IgG1, kappa

Storage :

4 C, store in dark

Description :

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

Immunogen :

Recombinant human Interleukin 10.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL / 1x10^6 cells

Aliases :

CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF

more info or order :

Invitrogen product webpage