CD8 Monoclonal Antibody (3B5), Qdot™ 705 | Invitrogen Q10059 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD8 Monoclonal Antibody (3B5), Qdot™ 705

catalog :

Q10059

quantity :

100 µL

price :

US 692.00

clonality :

monoclonal

host :

mouse

conjugate :

Qdot 705

clone name :

3B5

reactivity :

human, rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...	Riou C, Bunjun R, MÃ¼ller T, Kiravu A, Ginbot Z, Oni T, et al. Selective reduction of IFN-Î³ single positive mycobacteria-specific CD4+ T cells in HIV-1 infected individuals with latent tuberculosis infection. Tuberculosis (Edinb). 2016;101:25-30 pubmed publisher
flow cytometry; rhesus macaque; fig 1	Chowdhury A, Hayes T, Bosinger S, Lawson B, Vanderford T, Schmitz J, et al. Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques. J Virol. 2015;89:8677-86 pubmed publisher
flow cytometry; human	Deng N, Mosmann T. Optimization of the cytokine secretion assay for human IL-2 in single and combination assays. Cytometry A. 2015;87:777-83 pubmed publisher
flow cytometry; human	Karlsson F, Hassan Zahraee M. Quantification of Th1 and Th17 Cells with Intracellular Staining Following PMA/Ionomycin Stimulation. Curr Protoc Cytom. 2015;71:6.35.1-7 pubmed publisher
flow cytometry; human	Cichocki F, Schlums H, Li H, Stache V, Holmes T, Lenvik T, et al. Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency. J Exp Med. 2014;211:1079-91 pubmed publisher
flow cytometry; human	Deng N, Weaver J, Mosmann T. Cytokine diversity in the Th1-dominated human anti-influenza response caused by variable cytokine expression by Th1 cells, and a minor population of uncommitted IL-2+IFN?- Thpp cells. PLoS ONE. 2014;9:e95986 pubmed publisher
flow cytometry; human; loading ...; fig 5	Bridgeman J, Ladell K, Sheard V, Miners K, Hawkins R, Price D, et al. CD3Î¶-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. Clin Exp Immunol. 2014;175:258-67 pubmed publisher
flow cytometry; rhesus macaque; loading ...; fig 2a	Cervasi B, Carnathan D, Sheehan K, Micci L, Paiardini M, Kurupati R, et al. Immunological and virological analyses of rhesus macaques immunized with chimpanzee adenoviruses expressing the simian immunodeficiency virus Gag/Tat fusion protein and challenged intrarectally with repeated low doses of SIVmac. J Virol. 2013;87:9420-30 pubmed publisher
flow cytometry; human; fig 1	Li X, Miao H, Henn A, Topham D, Wu H, Zand M, et al. Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination. Vaccine. 2012;30:4581-4 pubmed publisher
flow cytometry; human; fig 1	Scheible K, Zhang G, Baer J, Azadniv M, Lambert K, Pryhuber G, et al. CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses. Vaccine. 2011;29:2159-68 pubmed publisher
flow cytometry; human	Chattopadhyay P, Melenhorst J, Ladell K, Gostick E, Scheinberg P, Barrett A, et al. Techniques to improve the direct ex vivo detection of low frequency antigen-specific CD8+ T cells with peptide-major histocompatibility complex class I tetramers. Cytometry A. 2008;73:1001-9 pubmed publisher
	Harper J, Huot N, Micci L, Tharp G, King C, Rascle P, et al. IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques. Nat Commun. 2021;12:2866 pubmed publisher
	Chitre A, Kattah M, Rosli Y, Pao M, Deswal M, Deeks S, et al. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018;14:e1006806 pubmed publisher
	Tanko R, Soares A, Müller T, Garrett N, Samsunder N, Abdool Karim Q, et al. Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women. J Immunol. 2017;198:1220-1228 pubmed publisher
	Ryan E, Micci L, Fromentin R, Paganini S, McGary C, Easley K, et al. Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques. PLoS Pathog. 2016;12:e1005412 pubmed publisher
	McGary C, Cervasi B, Chahroudi A, Micci L, Taaffe J, Meeker T, et al. Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques. J Virol. 2014;88:4533-42 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD8 Monoclonal Antibody (3B5), Qdot™ 705

Catalog # :

Q10059

Quantity :

100 µL

Price :

US 692.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent

Species :

Human

Clone :

3B5

Isotype :

IgG2a

Storage :

4° C, store in dark

Description :

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.

Immunogen :

Recognizes the CD8 antigen

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein

more info or order :

Invitrogen product webpage