CD8 Monoclonal Antibody (3B5), Qdot™ 605 | Invitrogen Q10009 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD8 Monoclonal Antibody (3B5), Qdot™ 605

catalog :

Q10009

quantity :

100 µL

price :

US 684.00

clonality :

monoclonal

host :

mouse

conjugate :

Qdot 605

clone name :

3B5

reactivity :

African green monkey, human, rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 20

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Stanisic D, Cutts J, Eriksson E, Fowkes F, Rosanas Urgell A, Siba P, et al. ?? T cells and CD14+ monocytes are predominant cellular sources of cytokines and chemokines associated with severe malaria. J Infect Dis. 2014;210:295-305 pubmed publisher
flow cytometry; African green monkey; 1:100; fig s6	Park S, Veerapu N, Shin E, Biancotto A, McCoy J, Capone S, et al. Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection. Nat Med. 2013;19:1638-42 pubmed publisher
flow cytometry; human; loading ...	Abdel Mohsen M, Raposo R, Deng X, Li M, Liegler T, Sinclair E, et al. Expression profile of host restriction factors in HIV-1 elite controllers. Retrovirology. 2013;10:106 pubmed publisher
flow cytometry; human; loading ...; fig 1	Zufferey C, Germano S, Dutta B, Ritz N, Curtis N. The contribution of non-conventional T cells and NK cells in the mycobacterial-specific IFNγ response in Bacille Calmette-Guérin (BCG)-immunized infants. PLoS ONE. 2013;8:e77334 pubmed publisher
flow cytometry; human; 1:400; loading ...; fig 3d	Raposo R, Abdel Mohsen M, Holditch S, Kuebler P, Cheng R, Eriksson E, et al. Increased expression of intrinsic antiviral genes in HLA-B*57-positive individuals. J Leukoc Biol. 2013;94:1051-9 pubmed publisher
flow cytometry; rhesus macaque; loading ...; fig 2a	Reuter M, Yuan S, Marx P, Kutzler M, Weiner D, Betts M. DNA-based HIV vaccines do not induce generalized activation in mucosal tissue T cells. Hum Vaccin Immunother. 2012;8:1648-53 pubmed publisher
flow cytometry; human	Frahm M, Picking R, Kuruc J, McGee K, Gay C, Eron J, et al. CD4+CD8+ T cells represent a significant portion of the anti-HIV T cell response to acute HIV infection. J Immunol. 2012;188:4289-96 pubmed publisher
flow cytometry; human; loading ...; fig 2b	Shaw J, Hunt P, Critchfield J, McConnell D, Garcia J, Pollard R, et al. Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol. 2011;85:11422-34 pubmed publisher
flow cytometry; human; fig S2	Ruffell B, Au A, Rugo H, Esserman L, Hwang E, Coussens L. Leukocyte composition of human breast cancer. Proc Natl Acad Sci U S A. 2012;109:2796-801 pubmed publisher
flow cytometry; human; loading ...; fig 2a	Kagina B, Abel B, Bowmaker M, Scriba T, Gelderbloem S, Smit E, et al. Delaying BCG vaccination from birth to 10 weeks of age may result in an enhanced memory CD4 T cell response. Vaccine. 2009;27:5488-95 pubmed publisher
	Kristensen N, Heeke C, Tvingsholm S, Borch A, Draghi A, Crowther M, et al. Neoantigen-reactive CD8+ T cells affect clinical outcome of adoptive cell therapy with tumor-infiltrating lymphocytes in melanoma. J Clin Invest. 2022;132: pubmed publisher
	Kjeldsen J, Lorentzen C, Martinenaite E, Ellebaek E, Donia M, Holmstroem R, et al. A phase 1/2 trial of an immune-modulatory vaccine against IDO/PD-L1 in combination with nivolumab in metastatic melanoma. Nat Med. 2021;27:2212-2223 pubmed publisher
	Chen H, Smith M, Herz J, Li T, Hasley R, Le Saout C, et al. The role of protease-activated receptor 1 signaling in CD8 T cell effector functions. iScience. 2021;24:103387 pubmed publisher
	Maleki K, Tauriainen J, García M, Kerkman P, Christ W, Dias J, et al. MAIT cell activation is associated with disease severity markers in acute hantavirus infection. Cell Rep Med. 2021;2:100220 pubmed publisher
	Antonarakis E, Small E, Petrylak D, Quinn D, Kibel A, Chang N, et al. Antigen-Specific CD8 Lytic Phenotype Induced by Sipuleucel-T in Hormone-Sensitive or Castration-Resistant Prostate Cancer and Association with Overall Survival. Clin Cancer Res. 2018;24:4662-4671 pubmed publisher
	Ogendi B, Bakshi R, Gupta K, Kapil R, Brown L, Jordan S, et al. T cell phenotypes in women with Chlamydia trachomatis infection and influence of treatment on phenotype distributions. Microbes Infect. 2018;20:176-184 pubmed publisher
	Ogendi B, Bakshi R, Sabbaj S, Brown L, Lee J, Kapil R, et al. Distinct peripheral vs mucosal T-cell phenotypes in chlamydia-infected women. Am J Reprod Immunol. 2017;78: pubmed publisher
	Chew G, Fujita T, Webb G, Burwitz B, Wu H, Reed J, et al. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016;12:e1005349 pubmed publisher
	Pacheco Y, McLean A, Rohrbach J, Porichis F, Kaufmann D, Kavanagh D. Simultaneous TCR and CD244 signals induce dynamic downmodulation of CD244 on human antiviral T cells. J Immunol. 2013;191:2072-81 pubmed publisher
	Long B, Stoddart C. OMIP-012: Phenotypic and numeric determination of human leukocyte reconstitution in humanized mice. Cytometry A. 2012;81:646-8 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD8 Monoclonal Antibody (3B5), Qdot™ 605

Catalog # :

Q10009

Quantity :

100 µL

Price :

US 684.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent

Species :

Human

Clone :

3B5

Isotype :

IgG2a

Storage :

4° C

Description :

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.

Immunogen :

Recognizes the CD8 antigen

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein

more info or order :

Invitrogen product webpage