This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-1 beta Polyclonal Antibody
catalog :
PP425
quantity :
1 mg
price :
US 309.00
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
pig
application :
western blot, ELISA
citations: 1
Published Application/Species/Sample/DilutionReference
  • ELISA; pig; loading ...; tbl 3
Wyns H, Croubels S, Demeyere K, Watteyn A, De Backer P, Meyer E. Development of a cytometric bead array screening tool for the simultaneous detection of pro-inflammatory cytokines in porcine plasma. Vet Immunol Immunopathol. 2013;151:28-36 pubmed publisher
product information
Product Type :
Antibody
Product Name :
IL-1 beta Polyclonal Antibody
Catalog # :
PP425
Quantity :
1 mg
Price :
US 309.00
Clonality :
Polyclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Porcine
Applications :
Western Blot: Assay Dependent
Species :
Porcine
Isotype :
IgG
Storage :
-20°C
Description :
Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Immunogen :
Recombinant porcine IL-1 beta
Format :
Liquid
Applications w/Dilutions :
Western Blot: Assay Dependent
Aliases :
IL-1 beta; interleukin-1 beta; prointerleukin-1 beta; IL-1beta
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA