Human EGF Recombinant Protein | Invitrogen PHG0313 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human EGF Recombinant Protein

catalog :

PHG0313

quantity :

1 mg

price :

US 592.00

citations: 14

Reference
Luo Y, Yamada M, N Tumba Byn T, Asif H, Gao M, Hu Y, et al. SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†. Biol Reprod. 2023;109:533-551 pubmed publisher
Zhao Y, Jin H, Kim D, Jung S, Liu S, Wan J, et al. SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer. Mol Carcinog. 2023;: pubmed publisher
Kadur Lakshminarasimha Murthy P, Sontake V, Tata A, Kobayashi Y, Macadlo L, Okuda K, et al. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Nature. 2022;604:111-119 pubmed publisher
Tsoi H, Shi L, Leung M, Man E, So Z, Chan W, et al. Overexpression of BQ323636.1 Modulated AR/IL-8/CXCR1 Axis to Confer Tamoxifen Resistance in ER-Positive Breast Cancer. Life (Basel). 2022;12: pubmed publisher
Scheidmann M, Castro Giner F, Strittmatter K, Krol I, Paasinen Sohns A, Scherrer R, et al. An in vivo CRISPR screen identifies stepwise genetic dependencies of metastatic progression. Cancer Res. 2021;: pubmed publisher
Low J, Lau D, Zhang X, Kwang X, Rohatgi N, Chan J, et al. A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC). EBioMedicine. 2021;64:103220 pubmed publisher
Papke C, Smolen K, Swingle M, Cressey L, Heng R, Toporsian M, et al. A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. J Biol Chem. 2021;296:100313 pubmed publisher
Ulukan B, Bihorac A, Sipahioglu T, Kiraly R, Fesus L, Telci D. Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. ACS Omega. 2020;5:28273-28284 pubmed publisher
Wu Y, Sarkissyan M, Ogah O, Kim J, Vadgama J. Expression of MALAT1 Promotes Trastuzumab Resistance in HER2 Overexpressing Breast Cancers. Cancers (Basel). 2020;12: pubmed publisher
Pan L, Li Y, Jin L, Li J, Xu A. TRPM2-AS promotes cancer cell proliferation through control of TAF15. Int J Biochem Cell Biol. 2020;120:105683 pubmed publisher
Sayoc Becerra A, Krishnan M, Fan S, Jimenez J, HERNANDEZ R, Gibson K, et al. The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction. Inflamm Bowel Dis. 2020;26:407-422 pubmed publisher
Li Y, Wang R, Xiong S, Wang X, Zhao Z, Bai S, et al. Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling. J Mol Med (Berl). 2019;97:243-255 pubmed publisher
Staberg M, Rasmussen R, Michaelsen S, Pedersen H, Jensen K, Villingshøj M, et al. Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B. Mol Oncol. 2018;12:406-420 pubmed publisher
Zanotto Filho A, GonÃ§alves R, Klafke K, de Souza P, Dillenburg F, Carro L, et al. Inflammatory landscape of human brain tumors reveals an NFÎºB dependent cytokine pathway associated with mesenchymal glioblastoma. Cancer Lett. 2017;390:176-187 pubmed publisher

product information

Product Type :

Protein

Product Name :

Human EGF Recombinant Protein

Catalog # :

PHG0313

Quantity :

1 mg

Price :

US 592.00

Clonality :

Recombinant

Purity :

purified

Reactivity :

Human

Applications :

Control: Assay-dependent, ELISA: Assay-dependent, Functional Assay: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Storage :

4 C

Description :

EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.

Format :

Lyophilized

Applications w/Dilutions :

Control: Assay-dependent, ELISA: Assay-dependent, Functional Assay: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent

Aliases :

AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone