This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
protein
product name :
Human EGF Recombinant Protein
catalog :
PHG0311
quantity :
100 ug
price :
US 148.00
citations: 29
Reference
Tan I, Perez A, Lew R, Sun X, Baldwin A, Zhu Y, et al. Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis. Cell Rep. 2023;42:113339 pubmed publisher
Pal A, Gonzalez Malerva L, Eaton S, Xu C, Zhang Y, Grief D, et al. Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants. NPJ Breast Cancer. 2023;9:78 pubmed publisher
He Q, Gao L, Zhang F, Yao W, Wu J, Song N, et al. The FoxO1-ATGL axis alters milk lipolysis homeostasis through PI3K/AKT signaling pathway in dairy goat mammary epithelial cells. J Anim Sci. 2023;101: pubmed publisher
Chen Z, Qiao Z, Wirth C, Park H, Lu Q. Arrestin domain-containing protein 1-mediated microvesicles (ARMMs) protect against cadmium-induced neurotoxicity. Extracell Vesicle. 2023;2: pubmed publisher
Hameed J S F, Devarajan A, M S D, Bhattacharyya A, Shirude M, Dutta D, et al. PTEN-negative endometrial cancer cells protect their genome through enhanced DDB2 expression associated with augmented nucleotide excision repair. BMC Cancer. 2023;23:399 pubmed publisher
Jensen C, Clements A, Liou H, Ball L, Bethard J, Langlais P, et al. PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion. J Cell Biol. 2023;222: pubmed publisher
Hosios A, Wilkinson M, McNamara M, Kalafut K, Torrence M, Asara J, et al. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nat Metab. 2022;4:1792-1811 pubmed publisher
Huang L, Luo J, Gao W, Song N, Tian H, Zhu L, et al. CRISPR/Cas9-Induced Knockout of miR-24 Reduces Cholesterol and Monounsaturated Fatty Acid Content in Primary Goat Mammary Epithelial Cells. Foods. 2022;11: pubmed publisher
Huang L, Luo J, Song N, Gao W, Zhu L, Yao W. CRISPR/Cas9-Mediated Knockout of miR-130b Affects Mono- and Polyunsaturated Fatty Acid Content via PPARG-PGC1α Axis in Goat Mammary Epithelial Cells. Int J Mol Sci. 2022;23: pubmed publisher
Magalhães Novais S, Blecha J, Naraine R, Mikešová J, Abaffy P, Pecinova A, et al. Mitochondrial respiration supports autophagy to provide stress resistance during quiescence. Autophagy. 2022;:1-18 pubmed publisher
Frisari S, Santo M, Hosseini A, Manzati M, Giugliano M, Mallamaci A. Multidimensional Functional Profiling of Human Neuropathogenic FOXG1 Alleles in Primary Cultures of Murine Pallial Precursors. Int J Mol Sci. 2022;23: pubmed publisher
Kumar R, Landry A, Guha A, Vitvitsky V, Lee H, Seike K, et al. A redox cycle with complex II prioritizes sulfide quinone oxidoreductase-dependent H2S oxidation. J Biol Chem. 2022;298:101435 pubmed publisher
Dong X, Zhang Q, Hao J, Xie Q, Xu B, Zhang P, et al. Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC. Front Oncol. 2021;11:754206 pubmed publisher
Cen B, Wei J, Wang D, Xiong Y, Shay J, DuBois R. Mutant APC promotes tumor immune evasion via PD-L1 in colorectal cancer. Oncogene. 2021;40:5984-5992 pubmed publisher
Zhang S, Zhou J, Fan Q, Lv X, Wang T, Wang F, et al. Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation. Exp Ther Med. 2021;22:829 pubmed publisher
Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, et al. Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 2020;32:107909 pubmed publisher
Pan L, Li Y, Jin L, Li J, Xu A. TRPM2-AS promotes cancer cell proliferation through control of TAF15. Int J Biochem Cell Biol. 2020;120:105683 pubmed publisher
Sayoc Becerra A, Krishnan M, Fan S, Jimenez J, HERNANDEZ R, Gibson K, et al. The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction. Inflamm Bowel Dis. 2020;26:407-422 pubmed publisher
Chen G, Park D, Magis A, Behera M, Ramalingam S, Owonikoko T, et al. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer Res. 2019;79:6126-6138 pubmed publisher
Teow S, Liew K, Che Mat M, Marzuki M, Abdul Aziz N, Chu T, et al. Development of a luciferase/luciferin cell proliferation (XenoLuc) assay for real-time measurements of Gfp-Luc2-modified cells in a co-culture system. BMC Biotechnol. 2019;19:34 pubmed publisher
Li Y, Wang R, Xiong S, Wang X, Zhao Z, Bai S, et al. Cancer-associated fibroblasts promote the stemness of CD24+ liver cells via paracrine signaling. J Mol Med (Berl). 2019;97:243-255 pubmed publisher
Sartor G, Malvezzi A, Kumar A, Andrade N, Wiedner H, Vilca S, et al. Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins. J Neurosci. 2019;39:612-626 pubmed publisher
Vantaggiato C, Panzeri E, Castelli M, Citterio A, Arnoldi A, Santorelli F, et al. ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis. Autophagy. 2019;15:34-57 pubmed publisher
O Malley Y, Rotti P, Thornell I, Vanegas Calderón O, Febres Aldana C, Durham K, et al. Development of a polarized pancreatic ductular cell epithelium for physiological studies. J Appl Physiol (1985). 2018;125:97-106 pubmed publisher
Staberg M, Rasmussen R, Michaelsen S, Pedersen H, Jensen K, Villingshøj M, et al. Targeting glioma stem-like cell survival and chemoresistance through inhibition of lysine-specific histone demethylase KDM2B. Mol Oncol. 2018;12:406-420 pubmed publisher
Li K, Hu C, Xing F, Gao M, Liang J, Xiao X, et al. Deficiency of the IRE1?-Autophagy Axis Enhances the Antitumor Effects of the Oncolytic Virus M1. J Virol. 2018;92: pubmed publisher
Kurapati S, Sadaoka T, Rajbhandari L, Jagdish B, Shukla P, Ali M, et al. Role of the JNK Pathway in Varicella-Zoster Virus Lytic Infection and Reactivation. J Virol. 2017;91: pubmed publisher
Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, et al. L2hgdh Deficiency Accumulates l-2-Hydroxyglutarate with Progressive Leukoencephalopathy and Neurodegeneration. Mol Cell Biol. 2017;37: pubmed publisher
Zanotto Filho A, Gonçalves R, Klafke K, de Souza P, Dillenburg F, Carro L, et al. Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma. Cancer Lett. 2017;390:176-187 pubmed publisher
product information
Product Type :
Protein
Product Name :
Human EGF Recombinant Protein
Catalog # :
PHG0311
Quantity :
100 ug
Price :
US 148.00
Clonality :
Recombinant
Purity :
purified
Reactivity :
Human
Applications :
Control: Assay-dependent, ELISA: Assay-dependent, Functional Assay: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent
Species :
Human
Storage :
4 C
Description :
EGF (Epidermal growth factor) exerts its actions by binding to the EGF Receptor, a 170 kDa protein kinase. Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. Each dimeric receptor complex initiates a distinct signaling pathway by recruiting different Src homology 2 (SH2) containing effector proteins. EGF is far and wide expressed in kidney, cerebrum, prostrate and salivary glands. EGF acts as a potent mitogenic factor and the phosphorylated receptor recruits adapter proteins like GRB2 that activates complex downstream signaling cascades. EGF activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STAT modules. Research studies suggest the protein may also play important role in activating the NF-kappa-B signaling cascade. Defects in the EGGF gene are the cause of hypomagnesemia type 4 and dysregulation has been associated with the growth and progression of certain cancers.
Format :
Lyophilized
Applications w/Dilutions :
Control: Assay-dependent, ELISA: Assay-dependent, Functional Assay: Assay-dependent, Immunohistochemistry: Assay-dependent, Western Blot: Assay-dependent
Aliases :
AI790464; beta-urogastrone; EGF; Epidermal growth factor; epidermal growth factor (beta-urogastrone); epidermal growth factor precursor; H-EGF; HOMG4; Pro-epidermal growth factor; Pro-epidermal growth factor precursor (EGF); sb:eu639; URG; Urogastrone
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA