Human IRS1 (aa 631-646) Synthetic Peptide | Invitrogen PEP-185 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Human IRS1 (aa 631-646) Synthetic Peptide

catalog :

PEP-185

quantity :

50 ug

price :

US 167.00

citations: 5

Reference
Rivera Chávez F, Lopez C, Zhang L, García Pastor L, Chávez Arroyo A, Lokken K, et al. Energy Taxis toward Host-Derived Nitrate Supports a Salmonella Pathogenicity Island 1-Independent Mechanism of Invasion. MBio. 2016;7: pubmed publisher
Winter S, Winter M, Poon V, Keestra A, Sterzenbach T, Faber F, et al. Salmonella enterica Serovar Typhi conceals the invasion-associated type three secretion system from the innate immune system by gene regulation. PLoS Pathog. 2014;10:e1004207 pubmed publisher
Rivera Chávez F, Winter S, Lopez C, Xavier M, Winter M, Nuccio S, et al. Salmonella uses energy taxis to benefit from intestinal inflammation. PLoS Pathog. 2013;9:e1003267 pubmed publisher
Brzóstkowska M, Raczkowska A, Brzostek K. OmpR, a response regulator of the two-component signal transduction pathway, influences inv gene expression in Yersinia enterocolitica O9. Front Cell Infect Microbiol. 2012;2:153 pubmed publisher
Crawford R, Keestra A, Winter S, Xavier M, Tsolis R, Tolstikov V, et al. Very long O-antigen chains enhance fitness during Salmonella-induced colitis by increasing bile resistance. PLoS Pathog. 2012;8:e1002918 pubmed publisher

product information

Product Type :

Peptide

Product Name :

Human IRS1 (aa 631-646) Synthetic Peptide

Catalog # :

PEP-185

Quantity :

50 ug

Price :

US 167.00

Clonality :

Synthetic

Purity :

purified

Reactivity :

Human

Applications :

Control: Assay-dependent

Species :

Human

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

IRS-1, a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor.

Format :

Lyophilized

Applications w/Dilutions :

Control: Assay-dependent

Aliases :

G972R; HIRS-1; Insulin receptor substrate 1; IRS1; IRS-1; IRS1IRM; pp185