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protein

Human DRAM Synthetic Peptide

PEP-0455

50 ug

US 167.00

Human DRAM Synthetic Peptide

PEP-0455

50 ug

US 167.00

Synthetic

purified

Human

Blocking Assay: Assay-dependent, Control: Assay-dependent

Human

-20 C

Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.

Liquid

Blocking Assay: Assay-dependent, Control: Assay-dependent

1200002N14Rik; Damage-regulated autophagy modulator; DNA damage regulated autophagy modulator 1; DNA damage-regulated autophagy modulator protein 1; DNA-damage regulated autophagy modulator 1; DRAM; Dram1; FLJ11259; hypothetical protein FLJ11259; zgc:101811