Avian Influenza NS1 Synthetic Peptide | Invitrogen PEP-0395 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

protein

product name :

Avian Influenza NS1 Synthetic Peptide

catalog :

PEP-0395

quantity :

50 ug

price :

US 167.00

product information

Product Type :

Peptide

Product Name :

Avian Influenza NS1 Synthetic Peptide

Catalog # :

PEP-0395

Quantity :

50 ug

Price :

US 167.00

Clonality :

Synthetic

Purity :

purified

Reactivity :

Virus

Applications :

Blocking Assay: Assay-dependent, Control: Assay-dependent

Species :

Virus

Storage :

-20 C

Description :

Influenza A H1N1 NS, also known as Non-structural protein 1 or NS1A or NS1, is a 234 amino acid containing protein belonging to the Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1) which has aves, human and pig as host. This protein belongs to the influenza A viruses NS1 family and is a homodimer located in the nucleus of uninfected, transfected cells, and in the cytoplasm of infected cells. The viral protein NS1 binds to and inhibits two cellular proteins that are required for the 3'-end processing of cellular pre-mRNAs which include the 30 kDa cleavage and polyadenylation specificity factor (CPSF4) and the poly(A)-binding protein 2 (PABPN1). Thus inhibiting post-transcriptional processing of cellular pre-mRNA and leading to accumulation of unprocessed 3' end pre-mRNAs in nucleus and loss of cellular protein synthesis. This helps the virus to escape interferon synthesis after activation of the IRF3 pathway, and therefore prevents establishment of cellular antiviral state. NS1 is also known to prevent human EIF2AK2/PKR activation, at the very beginning of the infection, when NS1 is mainly present in the cytoplasm and prevent antiviral response.

Format :

Liquid

Applications w/Dilutions :

Blocking Assay: Assay-dependent, Control: Assay-dependent