Caspase 1 p20 (Cleaved Asp296) Polyclonal Antibody | Invitrogen PA5-99390 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 1 p20 (Cleaved Asp296) Polyclonal Antibody

catalog :

PA5-99390

quantity :

100 uL

price :

US 440.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 10

Reference
Li W, Fan P, Wang X, Tang H. Loganin alleviates myocardial ischemia-reperfusion injury through GLP-1R/NLRP3-mediated pyroptosis pathway. Environ Toxicol. 2023;38:2730-2740 pubmed publisher
Sun L, Ding M, Chen F, Zhu D, Xie X. Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy. Peerj. 2023;11:e14826 pubmed publisher
Wang S, Sun M, Ding S, Liu C, Wang J, Han S, et al. Ticagrelor reduces doxorubicin-induced pyroptosis of rat cardiomyocytes by targeting GSK-3β/caspase-1. Front Cardiovasc Med. 2022;9:1090601 pubmed publisher
Zuo R, Li X, He Y. Ropivacaine has the potential to relieve PM2.5-induced acute lung injury. Exp Ther Med. 2022;24:549 pubmed publisher
Sala R, Rioja Blanco E, Serna N, S xe1 nchez Garc xed a L, xc1 lamo P, Alba Castell xf3 n L, et al. GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases. Drug Deliv. 2022;29:1384-1397 pubmed publisher
Chai Y, Cai Y, Fu Y, Wang Y, Zhang Y, Zhang X, et al. Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway. Front Pharmacol. 2022;13:812362 pubmed publisher
Cai Y, Chai Y, Fu Y, Wang Y, Zhang Y, Zhang X, et al. Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis. Front Aging Neurosci. 2021;13:809433 pubmed publisher
Zhang L, Qiu J, Shi J, Liu S, Zou H. MicroRNA-140-5p represses chondrocyte pyroptosis and relieves cartilage injury in osteoarthritis by inhibiting cathepsin B/Nod-like receptor protein 3. Bioengineered. 2021;12:9949-9964 pubmed publisher
Liu C, Cai B, Li D, Yao Y. Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation. Innate Immun. 2021;27:437-447 pubmed publisher
Tao Y, Wang F, Xu Z, Lu X, Yang Y, Wu J, et al. Gasdermin D in peripheral nerves: the pyroptotic microenvironment inhibits nerve regeneration. Cell Death Discov. 2021;7:144 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Caspase 1 p20 (Cleaved Asp296) Polyclonal Antibody

Catalog # :

PA5-99390

Quantity :

100 uL

Price :

US 440.00

Clonality :

Polyclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Rat

Isotype :

IgG

Storage :

-20 C

Description :

Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala. This cleavage causes the release of the mature cytokine which is involved in a variety of inflammatory processes. CASP1 is important for defense against pathogen. It cleaves and activates sterol regulatory element binding proteins (SREBPs). CASP1 also promotes apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, CASP1 controls antiviral immunity through the cleavage of CGAS and renders it inactive.

Immunogen :

A synthesized peptide derived from human CASP1(Accession P29466), corresponding to amino acid residues I280-V299.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500-1:2,000

Aliases :

CASP1; CASP-1; CASP1 nirs variant 1; caspase 1; caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase); caspase-1; Caspase-1 subunit p10; Caspase-1 subunit p20; Ice; IL-1 beta-converting enzyme; IL-1B converting enzyme; IL1BC; IL-1BC; IL1BCE; IL1B-convertase; interleukin 1 beta-converting enzyme; interleukin 1, beta, convertase; interleukin 1-B converting enzyme; Interleukin 1beta converting enzyme; interleukin-1 beta convertase; Interleukin-1 beta-converting enzyme; p45