SAV1 Polyclonal Antibody | Invitrogen PA5-98927 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SAV1 Polyclonal Antibody

catalog :

PA5-98927

quantity :

100 uL

price :

US 464.00

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

SAV1 Polyclonal Antibody

Catalog # :

PA5-98927

Quantity :

100 uL

Price :

US 464.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:20-1:500, Western Blot: 1:500-1:5,000

Species :

Human

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

Immunogen :

Recombinant Human Protein salvador homolog 1 protein (1-210AA)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:20-1:500, Western Blot: 1:500-1:5,000

Aliases :

1700040G09Rik; 45 kDa WW domain protein; EMBL:CAJ98868.1}; hWW45; mWW45; Protein salvador homolog 1; rWW45; Salv; salvador family WW domain containing protein 1; salvador homolog 1; salvador homolog 1 (Drosophila); Salvador homolog 1 protein; salvador-like protein 1-like protein; Sav; Sav1; sav1 {ECO:0000312; WW domain-containing adaptor 45; WW domain-containing protein 3; WW domain-containing protein 4; WW45; WW45 protein; Wwp3; Wwp4